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The clinical and biological significance of the transitional mucosa adjacent to colorectal cancer

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Abstract

The underlying nature of the transitional mucosa adjacent to colorectal cancer is defined and the evidence for and against the statement that this transitional mucosa involves primary premalignant change presented in this article. An association between mucin histochemical changes at the margins of resection and a poorer clinical outcome of patients has been recognized in patients with colorectal cancer after surgery. The retained transitional mucosa at the margins of resection appears to correlate with tumor recurrence and a poorer survival in patients who have undergone radical resection. It is considered that the transitional mucosa adjacent to colorectal cancer and its presence at the margins of resection may be an important prognostic marker for patients with large bowel cancer following radical resection.

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Authors and Affiliations

  1. The Department of General Surgery, Chang Zheng Hospital, Second Military Medical University, 428 Feng Yang Road, 200003, Shanghai, People's Republic of China

    Qiang Wang MD, Han Gao, Yanhe Wang & Yonglian Chen

  2. Department of Histopathology, Chang Zheng Hospital, Second Military Medical University, 428 Feng Yang Road, 200003, Shanghai, People's Republic of China

    Qiang Wang MD, Han Gao, Yanhe Wang & Yonglian Chen

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  1. Qiang Wang MD
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Wang, Q., Gao, H., Wang, Y. et al. The clinical and biological significance of the transitional mucosa adjacent to colorectal cancer. The Japanese Journal of Surgery 21, 253–261 (1991). https://doi.org/10.1007/BF02470943

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