Skip to main content
SpringerLink
Log in

Flow cytometric DNA analysis of neuroblastoma: Correlation with prognostic variables and survival of patients

  • Short Communication
  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

The DNA ploidy of tumor tissues obtained from 41 patients with neuroblastoma, or ganglioneuroblastoma, which is the histologic variant of neuroblastoma, was determined by flow cytometry. The DNA ploidy was diploid in 7 tumors (5 neuroblastomas and 2 ganglioneuroblastomas) and aneuploid in 34 tumors (20 neuroblastomas and 14 ganglioneuroblastomas). The DNA ploidy of tumor cells did not correlate with the survival of patients and there was no correlation between the DNA ploidy of tumor cells and such prognostic variables, histology, primary site, staging of tumors and operative curability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Laerum OD, Farsund T. Clinical application of flow cytometry: A review. Cytometry 1981; 2: 1–13.

    Article  PubMed  CAS  Google Scholar 

  2. Barlogie B, Raber MN, Schumann J, Johnson TS, Drewinko B, Goehde W, Andreeff M, Freireich EJ. Flow cytometry in clinical research. Cancer Res 1983; 43: 3982–3997.

    PubMed  CAS  Google Scholar 

  3. Friedlander ML, Hedley DW, Taylor IW. Clinical and biological significance of aneuploidy in human tumors. J Clin Pathol 1984; 37: 961–974.

    PubMed  CAS  Google Scholar 

  4. Look AT, Hayes FA, Nitschke R, McWilliams NB, Green AA. Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma. N Engl J Med 1984; 311; 231–235.

    Article  PubMed  CAS  Google Scholar 

  5. Gansler T, Chatten J, Varello M, Bunin GR, Atkinson B. Flow cytometric DNA analysis of neuroblastoma: Correlation with histology and clinical outcome. Cancer 1986; 58: 2453–2458.

    Article  PubMed  CAS  Google Scholar 

  6. Evans A, D'Angio GJ, Randolph JA. A proposed staging for children with neuroblastoma. Cancer 1971; 27: 347–348.

    Article  Google Scholar 

  7. Stephenson RA, Gay H, Fair WR, Melamed MR. Effect of thickness on quality of flow cytometric DNA content determinations in paraffin-embedded tissues. Cytometry 1986; 7: 41–44.

    Article  PubMed  CAS  Google Scholar 

  8. Hedley DW, Friedlander ML, Taylor IW. Application of DNA flow cytometry to paraffin-embedded archival material for the study of aneuploidy and its clinical significance. Cytometry 1985; 6: 327–333.

    Article  PubMed  CAS  Google Scholar 

  9. Feicher GE, Goerttler K, Haag D, Heep J, Höpker WW, Kaufmann M, Krämer KL, Kubli F, Kühn W, Kunze St. Maier H, Müller A, Rummel H, Schlag P, Schwechheimer K. DNA Messung von malignen Tumoren mittels Impulszytometrie. Dtsch Med Wochenschr 1984; 109: 738–744.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Second Department of Surgery, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Japan

    Hiroshi Suzuki MD & Kenji Takeuchi

Authors
  1. Hiroshi Suzuki MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenji Takeuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Suzuki, H., Takeuchi, K. Flow cytometric DNA analysis of neuroblastoma: Correlation with prognostic variables and survival of patients. The Japanese Journal of Surgery 18, 116–118 (1988). https://doi.org/10.1007/BF02470858

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02470858

Key Words

Search

Navigation