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Combined effects of UFT with other anticancer agents using in vivo chemosensitivity tests

The Japanese journal of surgery volume 18, pages 93–97 (1988)Cite this article

Abstract

In order to estimate the combined effects of UFT with other anticancer agents, a nude mouse experimental system (NMES), and a subrenal capsule assay (SRCA) were investigated. Three human tumor xenografts were serially transplanted into nude mice and examined. These were; EH-1 established from esophageal cancer, SH-6 from gastric cancer and CH-3 from colon cancer. The antiproliferative effects were estimated in accordance with the NCI therapeutic protocol. Significant antiproliferative effects were obtained only in NMES and a positive relationship was observed between the two assays (p<0.05). In the groups which were treated with a single agent, positive tumor responses were observed against mitomycin C in SH-6, against cis-DD platinum in SH-6 and EH-1, and against adriamycin in EH-1, respectively. On this study the synergistic, additive and subadditive effects were defined as the positive combined effects. The combination of MMC and UFT produced positive combined effects for all xenografts in both assays.

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Affiliations

  1. Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734, Hiroshima, Japan

    Masahiko Nishiyama MD, Ken Niimi, Shinichi Takagami, Naoki Hirabayashi, Masahiro Yamaguchi, Toshiaki Saeki, Ken Yoshinaka, Wang Dian-Chang, Minoru Niimoto & Takao Hattori

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  1. Masahiko Nishiyama MD
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  2. Ken Niimi
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  3. Shinichi Takagami
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  4. Naoki Hirabayashi
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  5. Masahiro Yamaguchi
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  6. Toshiaki Saeki
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  7. Ken Yoshinaka
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  8. Wang Dian-Chang
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  9. Minoru Niimoto
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  10. Takao Hattori
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Nishiyama, M., Niimi, K., Takagami, S. et al. Combined effects of UFT with other anticancer agents using in vivo chemosensitivity tests. The Japanese Journal of Surgery 18, 93–97 (1988). https://doi.org/10.1007/BF02470852

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  • DOI: https://doi.org/10.1007/BF02470852

Key Words

  • anticancer agent
  • UFT
  • nude mouse experimental system
  • subrenal capsule assay