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The Japanese journal of surgery

, Volume 20, Issue 1, pp 115–118 | Cite as

Nuclear DNA content in breast carcinoma with special reference to the parameters of malignant potentiality

  • Shin-ichi Suehiro
  • Yuzo Hamada
  • Masakazu Toi
  • Takashi Nakamura
  • Minoru Niimoto
  • Takao Hattori
Short Communications
  • 14 Downloads

Abstract

Nuclear DNA ploidy pattern was examined in 22 breast carcinomas with a tumor mass of up to 2.2 cm and compared with the clinical and histological parameters of the malignant potentiality of breast carcinomas. The 22 carcinomas were divided into 11 aneuploid and 11 near-diploid carcinomas. It was found that the histological type, histological grade, nuclear grade, mitotic index and lymphatic invasion were either only slightly, or not correlated at all with the DNA ploidy pattern. Nevertheless, lymph node metastasis and negative estrogen receptor status was more frequently seen in the patients with aneuploid carcinoma than in those with near-diploid carcinoma.

Key Words

breast carcinoma DNA ploidy pattern estrogen receptor 

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Copyright information

© The Japan Surgical Society 1990

Authors and Affiliations

  • Shin-ichi Suehiro
    • 1
  • Yuzo Hamada
    • 1
  • Masakazu Toi
    • 1
  • Takashi Nakamura
    • 1
  • Minoru Niimoto
    • 1
  • Takao Hattori
    • 1
  1. 1.The Department of Surgery, Research Institute for Nuclear Medicine and BiologyHiroshima UniversityHiroshimaJapan

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