The Japanese journal of surgery

, Volume 17, Issue 4, pp 307–311 | Cite as

Gastric cancer with synchronous unresectable hepatic metastasis and a positive response to chemotherapy —Report of two cases—

  • Shigeru Fujimoto
  • Ram Dhoj Shrestha
  • Junji Kasanuki
  • Masashi Kokubun
  • Noboru Ichiki
  • Akira Miyazaki
  • Masayasu Ohta
  • Katsuji Okui
Case Reports
  • 25 Downloads

Abstract

We report herein the clinical events seen in two longterm survivors of gastric cancer with unresectable synchronous hepatic metastases. Partial gastrectomy was performed against the primary lesion and continuous intra-arterial infusion of anti-tumor drugs, followed by prolonged systemic antitumor drug treatment, were prescribed. A 43-year-old man with moderately-differentiated tubular adenocarcinoma had an uneventful course during his first 21 postoperative months. However, multiple liver metastases became manifest at 24 months and enlargement of the intrahepatic foci led to death 27 months after gastrectomy. A 51-year-old woman with moderagely-differentiated tubular adenocarcinoma had an uneventful postoperative course and is now well with no signs of recurrence 6 years and 6 months after gastrectomy.

Key Words

gastric cancer liver metastasis intra-arterial chemotherapy long-term survivor 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adson MA, van Heerden JA. Major hepatic resections for metastatic colorectal cancer. Ann Surg 1980; 191: 576–583.PubMedGoogle Scholar
  2. 2.
    Iwatsuki S, Shaw BW Jr, Starzl TE. Experience with 150 liver resections. Ann Surg 1983; 197: 247–253.PubMedGoogle Scholar
  3. 3.
    Balch CM, Urist MM, Soong S-J, McGregor M. A propective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg 1983; 198: 567–573.PubMedCrossRefGoogle Scholar
  4. 4.
    Niederhuber JE, Ensminger W, Gyves J, Thrall J, Walker S, Cozzi E. Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer 1984; 53: 1336–1343.PubMedCrossRefGoogle Scholar
  5. 5.
    Fujimoto S, Kitsukawa Y, Itoh K. Carcinoembryonic antigen (CEA) in gastric juice or feces as an aid in the diagnosis of gastrointestinal cancer. Ann Surg 1979; 189: 34–38.PubMedGoogle Scholar
  6. 6.
    Japanese Research Society for Gastric Cancer. The general rules for the gastric cancer study in surgery and pathology. Jpn J Surg 1981; 11: 127–139.CrossRefGoogle Scholar
  7. 7.
    Jaffe BM, Donegan WL, Watson F, Spratt JS. Factors influencing survival in patients with untreated hepatic metastases. Surg Gynecol Obstet 1968; 127: 1–11.PubMedGoogle Scholar
  8. 8.
    Fujimoto S, Miyazaki M, Okui K. Antitumor treatment for synchronous hepatic metastasis from stomach cancer. J Jpn Soc Cancer Ther 1982; 17: 1864–1872.Google Scholar
  9. 9.
    Okuyama K, Isono K, Juan I-K, Onoda S, Ochiai T, Yamamoto Y, Koide Y, Satoh H. Evaluation of treatment for gastric cancer with liver metastasis. Cancer 1985; 55: 2498–2505.PubMedCrossRefGoogle Scholar

Copyright information

© The Japan Surgical Society 1987

Authors and Affiliations

  • Shigeru Fujimoto
    • 1
  • Ram Dhoj Shrestha
    • 1
  • Junji Kasanuki
    • 2
  • Masashi Kokubun
    • 1
  • Noboru Ichiki
    • 3
  • Akira Miyazaki
    • 4
  • Masayasu Ohta
    • 1
  • Katsuji Okui
    • 1
  1. 1.First Department of Surgery School of MedicineChiba UniversityChibaJapan
  2. 2.Second Department of Internal Medicine, School of MedicineChiba UniversityChibaJapan
  3. 3.Division of SurgeryNational Sanatorium Shimoshizu HospitalJapan
  4. 4.Division of SurgerySumitomo Heavy Industries Uraga HospitalJapan

Personalised recommendations