The Japanese journal of surgery

, Volume 16, Issue 6, pp 406–411 | Cite as

Clinicopathological study on hematogenous metastasis of pancreatic cancer

  • Seiki Matsuno
  • Sumitomo Kato
  • Masao Kobari
  • Toshio Sato
Original Articles


Out of 272 pancreatic cancer patients, 94 with hematogenous metastasis were clinicopathologically analyzed. The incidence of hematogenous metastases on laparotomy was 31.3 per cent in the liver, 1.8 per cent in the lung, 1.1 per cent in the adrenal gland and 0.4 per cent in the navel, respectively. The incidence of liver metastasis, in 22.9 per cent of the patients with carcinoma of the head of the pancreas and in 47.3 per cent of those of the body and tail of the pancreas, was higher than that of carcinomas of the other digestive organs. In autopsy findings, early metastases to the liver, lung, cerebellum and ovarium were evident. A higher rate of liver metastasis with lymph node involvement in the early stage of the disease was peculiar to cases of pancreatic cancer.

Key Words

pancreatic cancer hematogenous metastasis liver metastasis pancreatectomy 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Japanese Pancreatic Society. General Rules for Surgical and Pathological Studies on Cancer of Pancreas, 2nd ed., Kanahara Publishing, Tokyo, 1982. (in Japanese)Google Scholar
  2. 2.
    Warren S, Meissner WA. Neoplasma, Pathology, Fifth edition Vol 1 ed. by Anderson, Mobsy Company, St. Louis, 1966; 400–429.Google Scholar
  3. 3.
    Kishi K, Hirota T, Nakamura K, Yoshimori M, Ohkura H, Ozaki H. Carcinoma of the pancreas: A review of 94 autopsy cases. Jpn J Clin Oncol 1980; 10: 273–279.Google Scholar
  4. 4.
    Sproul EE. Carcinoma and venous thrombosis; the frequency of association of carcinoma of the body and tail of the pancreas with multiple venous thrombosis. Am J Cancer 1938; 34: 566–585.Google Scholar
  5. 5.
    Matsuno S, Sato T. Problems in the surgical treatment for pancreatic cancer. Nippon Geka Gakkai Zasshi 1982; 83: 1051–1054. (English Abst.)Google Scholar
  6. 6.
    Mori W, Adachi Y, Okabe H, Oota K. An analysis of 755 autopsied cases of malignant tumors— A statistical study of their metastasis— Gan no Rinsho 1963; 9: 351–374. (in Japanese)Google Scholar
  7. 7.
    Yoshida K. Experimental studies on metastasis formation in the liver and lung by means of portal injection of the rats ascites hepatoma. Tohoku Igaku Zasshi 1961; 64: 107–117. (English Abst.)PubMedGoogle Scholar
  8. 8.
    Maki T, Majima S, Yoshida K, Karube K, Takahashi T, Machida T, Hoshi H, Ito K, Hiroki T, Kurata Y. Gastric cancer. Gan no Rinsho 1967; 13: 208–217. (in Japanese)PubMedGoogle Scholar
  9. 9.
    Cubilla, AL, Fitzgerald, PJ. Cancer of the pancreas (Nonendocrine): A suggested morphologic classification, Seminars in Oncology 1979; 6: 285–297.PubMedGoogle Scholar
  10. 10.
    Samitz MH. Umbilical metastasis from carcinoma of the stomach. Sister Joseph's nodule. Arch Dermatol 1975; 1: 1478–1479.CrossRefGoogle Scholar

Copyright information

© The Japan Surgical Society 1986

Authors and Affiliations

  • Seiki Matsuno
    • 1
  • Sumitomo Kato
    • 1
  • Masao Kobari
    • 1
  • Toshio Sato
    • 1
  1. 1.The First Department of SurgeryTohoku University, School of MedicineSendaiJapan

Personalised recommendations