The Japanese journal of surgery

, Volume 16, Issue 5, pp 367–370 | Cite as

Intrahepatic calculi associated with cholangiocarcinoma

  • Kazuyoshi Nishihara
  • Akitoshi Koga
  • Kinjiro Sumiyoshi
  • Kohji Kayashima
  • Eriko Koso
Case Reports

Abstract

A unique case of hepatolithiasis associated with cholangiocarcinoma is described. The intrahepatic calculi consisted mainly of cholesterol rather than calcium bilirubinate. A bacteriological study of the intrahepatic and gallbladder bile was negative, though bacterial infection of the bile duct has been considered a main factor responsible for formation of intrahepatic calculi.

Key Words

cholangiocarcinoma hepatolithiasis intrahepatic calculi 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Falchuk KR, Lesser PB, Galdbini JJ, Isselbacher KF. Cholangiocarcinoma as related to chronic intrahepatic cholangitis and hepatolithiasis. Am J Gastroenterol 1976; 66: 57–61.PubMedGoogle Scholar
  2. 2.
    Chen PH, Lo HW, Wang CS, Tsai KR, Chen YC, Lin KY, Siauw CP, Hwang RR, Lin MH, Ko HC, Chen TY. Cholangiocarcinoma in hepatolithiasis. J Clin Gastroenterol 1984; 6: 539–547.PubMedGoogle Scholar
  3. 3.
    Koga A, Ichimiya H, Yamaguchi K, Miyazaki K, Nakayama F. Hepatolithiasis associated with cholangiocarcinoma. Possible Etiologic Significance. Cancer 1985; 55: 2826–2829.PubMedCrossRefGoogle Scholar
  4. 4.
    Ikeda S, Tanaka M, Yoshimoto H, Itoh H, Nakayama F. Improved visualization of intrahepatic bile ducts by endoscopic retrograde balloon catheter cholangiography. Ann Surg 1985; 194: 171–175.CrossRefGoogle Scholar
  5. 5.
    Yamashita N. Composition of intrahepatic calculi: Etiological significance: Dig Dis Sci 1986. (in press)Google Scholar
  6. 6.
    Nakayama F. Quantitative microanalysis of gallstones. J Lab Clin Med 1968; 72: 602–611.PubMedGoogle Scholar
  7. 7.
    Nakayama F, Furusawa T, Nakama T. Hepatolithiasis in Japan: Present Status. Am J Surg 1980; 139: 216–220.PubMedCrossRefGoogle Scholar
  8. 8.
    Matsushiro T, Suzuki N, Sato T, Maki T. Effect of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones. Gastroenterology 1977; 72: 630–633.PubMedGoogle Scholar
  9. 9.
    Nagase M, Hikasa Y, Soloway RD, Tanimura H, Setoyama M, Kato H. Gallstones in western Japan. Factors affecting the prevalence of intrahepatic gallstones. Gastroenterology 1980; 78: 684–690.PubMedGoogle Scholar
  10. 10.
    Shimada H, Niimoto S, Matsuba A, Isobe Y, Miwa K, Nakagawara G, Nakano A, Kure H, Kobayashi M, Tsuchiya S. Primary cholesterol hepatolithiasis. Nippon Rinsho Geka-gakkai Zasshi 1985; 46: 442–448. (in Japanese)Google Scholar
  11. 11.
    Tabata M, Nakayama F. Bacteria and gallstones. Dig Dis Sci 1981; 26: 218–224.PubMedCrossRefGoogle Scholar
  12. 12.
    Glenn F, Moody FG. Intrahepatic calculi. Ann Surg 1961; 153: 711–724.PubMedGoogle Scholar
  13. 13.
    Goldin B, Gorback S. Activation of carcinogens by bacterial and microsomal enzyme system. Gastroenterology 1983; 85: 200–201.PubMedGoogle Scholar
  14. 14.
    Reddy BS, Watanabe K. Effect of cholesterol metabolites and promoting effect of lithocholic acid in colon carcinogens in germfree and conventional F344 Rats. Can Res 1979; 39: 1521–1524.Google Scholar
  15. 15.
    Gallagher PJ, Millis RR, Mitchinson MF. Congenital dilatation of the intrahepatic bile ducts with cholangiocarcinoma. J Clin Pathol 1972; 25: 804–808.PubMedGoogle Scholar
  16. 16.
    Jones AW, Shreeve DR. Congenital dilatation of intrahepatic biliary duct with carcinoma. Br Med J 1970; 2: 277–278.CrossRefPubMedGoogle Scholar
  17. 17.
    Blounstein PA. Association of carcinoma with congenital cystic conditions of the liver and bile ducts. Am J Gastroenterol 1977; 67: 40–46.Google Scholar
  18. 18.
    Phinney PR, Austin GE, Kadell BM. Cholangiocarcinoma arising in Caroli's disease. Arch Pathol Lab Med 1981; 105: 194–197.PubMedGoogle Scholar
  19. 19.
    Hou PC. The relationship between primary carcinoma of the liver and infestation with Clonorchis sinensis. J Pathol Bacteriol 1956; 72: 239–246.PubMedCrossRefGoogle Scholar
  20. 20.
    Hou PC. Primary carcinoma of bile ducts of the liver of the cats (felis catus) infested with Clonorchis sinensis. J Pathol Bacteriol 1964; 87: 239–244.PubMedCrossRefGoogle Scholar
  21. 21.
    Sanes S, MacCallum JD. Primary carcinoma of the liver. Cholangioma in hepatolithiasis. Am J Pathol 1942; 18: 675–683.PubMedGoogle Scholar
  22. 22.
    Nakanuma Y, Terada T, Tanaka Y, Ohta G. Are hepatolithiasis and cholangiocarcinoma aetiologically related? A morphological study of 12 cases of hepatolithiasis associated with cholangiocarcinoma. Virchows Arch A 1985; 406: 45–58.CrossRefGoogle Scholar
  23. 23.
    Warner R, Balch F Jr. Carcinoma of the gallbladder: the etiological role for gallstones. Surgery 1940; 7: 657–666.Google Scholar

Copyright information

© The Japan Surgical Society 1986

Authors and Affiliations

  • Kazuyoshi Nishihara
    • 1
  • Akitoshi Koga
    • 1
  • Kinjiro Sumiyoshi
    • 1
  • Kohji Kayashima
    • 1
  • Eriko Koso
    • 1
  1. 1.Department of Surgery IKyushu University, Faculty of MedicineFukuokaJapan

Personalised recommendations