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The Japanese journal of surgery

, Volume 16, Issue 5, pp 305–310 | Cite as

Clinical usefulness and false-positive results of CA 125 as a tumor marker of ovarian cancer —A study on 674 patients—

  • Kentaro Takahashi
  • Toshihiko Shibukawa
  • Masashi Moriyama
  • Takaaki Shirai
  • Satoshi Kijima
  • Osamu Iwanari
  • Isao Matsunaga
  • Manabu Kitao
Review Article

Abstract

To study the clinical usefulness and false-positive results of CA 125 as a tumor marker of ovarian cancer, we measured serum CA 125 levels in 197 patients with gynecological diseases, 274 normal, pregnant and postpartum women, 14 patients with abnormal pregnancy, 82 healthy women with a normal ovulatory menstrual cycle and 107 healthy non-pregnant subjects, using RIA kits. A level below 34 U/ml was considered the normal CA 125 range. The positive ratio of serum CA 125 in patients with malignant ovarian tumor was 81.3 per cent, and in those with serous cystadenocarcinoma the rate was 100 per cent. On the other hand, only one patient with benign ovarian tumor had a positive CA 125 value. Therefore, we suggest that CA 125 is useful for differentiation between benign ovarian tumor and ovarian cancer. However, because the positive ratio of CA 125 level is high in patients with recurrences of uterine cervical adenocarcinoma, those with tubal cancer, endometriosis, early pregnancy, abnormal pregnancy plus intrauterine fetal death and menstruating women, such situations must be given due attention when CA 125 is used as a tumor marker of ovarian cancer.

Key Words

ovarian cancer false-positive CA 125 tumour marker reproductive tract 

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References

  1. 1.
    Bast RC Jr, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H, Berkowitz RS, Leavitt T, Griffiths CT, Parker L, Zurawski VR, Knapp RC. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 1983; 309: 883–887.PubMedCrossRefGoogle Scholar
  2. 2.
    Bast RC Jr, Klug TL, Schaetzl E, Lavin P, Niloff JM, Greber TF, Zurawski VR Jr, Knapp RC. Monitoring human ovarian carcinoma with a combination of CA 125, CA 19-9, and carcinoembryonic antigen. Am J Obstet Gynecol 1984; 149: 553–559.PubMedGoogle Scholar
  3. 3.
    Klug RL, Bast RC Jr, Niloff JM, Knapp RC, Zurawski VR Jr. Monoclonal antibody immunoradiometric assay for an antigenic determinant (CA 125) associated with human epithelial ovarian carcinomas. Cancer Research 1984; 44: 1048–1053.PubMedGoogle Scholar
  4. 4.
    Takahashi K, Fukuda S, Yoshino K, Shibukawa T, Murao F, Kitao M. Diagnostic usefulness of serum CA 125 in patients with ovarian cancer. Shimane J Med Sci 1985; 9: 43–48.Google Scholar
  5. 5.
    Takahashi K, Yoshino K, Shibukawa T, Kitao M. The normal levels of an antigenic determinant CA 125 in healthy non-pregnant Japanese. The World of Obstetrics and Gynecology 1985; 37: 717–719.Google Scholar
  6. 6.
    Takahashi K, Yoshino K, Araki Y, Nishigaki A, Shirai T, Shibukawa T, Kitao M. Alterations in levels of CA 125 during the menstrual cycle. Jap J Fert Ster 1986; 31: 392–395.Google Scholar
  7. 7.
    Takahashi K, Kijima S, Yoshino K, Shibukawa T, Moriyama M, Iwanari O, Sawada K, Matsunaga I, Murao F, Kitao M. Differential diagnosis between leiomyomata uteri and adenomyosis using CA 125 as a new tumor marker of ovarian carcinoma. Nippon Sanka Fujinka Gakkai Zasshi (Acta Obst Gynaec Jpn) 1985; 37: 591–595. (English Abst.)PubMedGoogle Scholar
  8. 8.
    Takahashi K, Kijima S, Yoshino K, Shibukawa T, Murao F, Kitao M. Differential diagnosis between uterine myoma and endometriosis using CA 125 as a new tumor marker of ovarian carcinoma. Asia-Oceania J Obstet Gynaecol 1986; 12: 99–103.PubMedGoogle Scholar
  9. 9.
    Takahashi K, Nagata H, Yamane Y, Yoshino K, Shibukawa T, Murao F, Kitao M. Clinical usefulness of serum CA 125 in patients with endometriosis. Shimane J Med Sci 1986; 9: 82–88.Google Scholar
  10. 10.
    Takahashi K, Yamane Y, Yoshino K, Shibukawa T, Matsunaga I, Kitao M. Studies on serum CA 125 levels in pregnant women. Nippon Sanka Fujinka Gakkai Zasshi (Acta Obst Gynaec Jpn) 1985; 37: 1931–1934.PubMedGoogle Scholar
  11. 11.
    Kimura E, Murae M, Koga R, Odawara Y, Nakabayashi Y, Yokoyama K, Nakata H, Totake T, Ochiai K, Yasuda M, Terashima Y, Hachiya S. Clinical significance of a new tumor marker CA 125 in gynecological cancer—Particular usefulness in diagnosis of ovarian cancer. Nippon Sanka Fujinka Gakkai Zasshi (Acta Obst Gynaec Jpn) 1984; 36: 2121–2128. (English Abst.)PubMedGoogle Scholar
  12. 12.
    Saito S, Nakanishi A, Noda T, Ando Y, Katakami Y, Kiyozuka Y, Moriyama I, Ichijo M. Clinical usefulness of monoclonal antibody, CA 125 and CA 19-9 in ovarian cancer. Nippon Gan Chi Ryo Gakkai Zasshi (J Jpn Soc Cancer Ther) 1984; 19: 2327–2335. (English Abst.)Google Scholar

Copyright information

© The Japan Surgical Society 1986

Authors and Affiliations

  • Kentaro Takahashi
    • 1
  • Toshihiko Shibukawa
    • 1
  • Masashi Moriyama
    • 1
  • Takaaki Shirai
    • 1
  • Satoshi Kijima
    • 1
  • Osamu Iwanari
    • 1
  • Isao Matsunaga
    • 1
  • Manabu Kitao
    • 1
  1. 1.Department of Obstetrics and GynecologyShimane Medical UniversityIzumoJapan

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