Use of an intravenous branched chain amino acid enriched diet in the tumor-bearing rat
The purpose of this study was to determine whether a branched chain amino acids (BCAA) enriched intravenous feeding would have an effect on nitrogen retention in the host tissue, without stimulating tumor growth in the malignant tumor bearing animal. NEDH/c rats with an implanted fibrosarcoma were put on one of two total parenteral nutrition regimens, one of an amino acid formula containing 25 per cent BCAA, by weight and the other containing 50 per cent BCAA. Nitrogen retention in the two tumor-bearing groups was similar, although it was 47 per cent greater than observed in the non-tumor bearing animals (pº0.05). Skeletal protein synthesis was significantly reduced by the presence of the tumor in rats on the 25 per cent BCAA formula (from 10.1 per cent/day to 6.1 per cent/day) but was increased to 7.9 per cent/day by the 50 per cent BCAA formula. The BCAA enriched intravenous feeding does not enhance tumor growth and supports skeletal protein synthesis, at least in this experimental model.
Key Wordsbranched chain amino acid L-[U-14C] tyrosine skeletal protein synthesis
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- 1.Warren S. The immediate causes of death in cancer. Amer J Med Sci 1932; 184: 610–615.Google Scholar
- 11.Lundholm K, Bylund AC, Holm J, Schersten T. Skeletal muscle metabolism in patients with cancer. Europ J Cancer 1976; 12: 465–473.Google Scholar
- 15.Heddon MR, Buse MG. General stimulation of muscle protein synthesis by branched chain amino acidsin vitro. Proc Soc Exp Biol Med 1979; 160: 410–415.Google Scholar
- 16.Schaur RJ, Semmelrock HJ, Schrubmayer W, Tilliam HM, Schavenstein E. Tumor host relations: nitrogen metabolism in Yoshida sarcoma-bearing rats, reduction of growth rate and increase of survival time by administration of physiologic doses of branched chain amino acids. J Cancer Res Clin Oncol 1980; 97: 285–293.PubMedCrossRefGoogle Scholar