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Intra-hepato-arterial infusions of cis-diamminedichloroplatinum (II) and 5-fluorouracil clinically effective for malignant liver tumors

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Abstract

Four hepatocellular cancer patients and 11 metastatic liver cancer patients were treated with intra-hepato-arterial infusions of cis-diamminedichloroplatinum (II) plus 5-fluorouracil. Cis-diamminedichloroplatinum (II) (25–35 mg/m2) was given once a week, 5-fluorouracil (150–180 mg/m2) was infused daily. A partial response was obtained in 3 of 4 patients with primary cancer and in 5 of 9 evaluable metastatic cancer patients; the mean response durations were 27+ weeks in the former and 47+ weeks in the latter. However, severe bone marrow suppression occurred in 4 patients; 3 died of septicemia (2 cases) and massive intra-tracheal bleeding, respectively. This combined intra-hepato-arterial chemotherapy exerts a synergistic anticancer effect on malignant liver tumors, however, the related bone marrow suppression remains to be overcome.

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Authors and Affiliations

  1. Department of Surgery, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan

    Michio Maeta, Shigemasa Koga, Hiroshi Yoshioka, Atsunobu Murakami & Toshio Wakatsuki

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  1. Michio Maeta
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  2. Shigemasa Koga
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  3. Hiroshi Yoshioka
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  4. Atsunobu Murakami
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  5. Toshio Wakatsuki
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Maeta, M., Koga, S., Yoshioka, H. et al. Intra-hepato-arterial infusions of cis-diamminedichloroplatinum (II) and 5-fluorouracil clinically effective for malignant liver tumors. The Japanese Journal of Surgery 15, 318–320 (1985). https://doi.org/10.1007/BF02469923

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  • DOI: https://doi.org/10.1007/BF02469923

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