The Japanese journal of surgery

, Volume 15, Issue 3, pp 225–229 | Cite as

Radiation-induced esophageal carcinoma responded well to hyperthermic chemotherapy

A case report
  • Hidenobu Kai
  • Yasuhiro Yoshida
  • Hidemasa Matsufuji
  • Keizo Sugimachi
  • Kiyoshi Inokuchi
Case Reports

Abstract

A 66-year-old man with multiple malignant lesions of the esophagus, as apparently induced by irradiation of 60 Gy of60Co for a mediastinal tumor at the age of 36 y.o., was a poor operative risk because of severe lung disease. This man was treated with a combination of hyperthermia, oral administration of oil Bleomycin-polyacrylate paste and intravenous infusion of cis-Platinum. During 20 administrations of hyperthermia conducted at 42–45°C for 30 min, 600 mg of oil Bleomycin and 200 mg of cis-Platinum, no complications occurred and the heat treatments were completed with no side effects. Repeatedly performed esophagogram and endoscopy showed a complete disappearance of three of the four lesions and a marked regression in the other one. There has been no regrowth or distant spread of the carcinoma up to the present 10 months of follow up. This combination of hyperthermia and chemotherapy may prove to be the optimal strategy for treatment of unresectable esophageal cancer, particularly when radiotherapy is contraindicated.

Key Words

hyperthermia with chemotherapy esophageal cancer 

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Copyright information

© The Japan Surgical Society 1985

Authors and Affiliations

  • Hidenobu Kai
    • 1
  • Yasuhiro Yoshida
    • 1
  • Hidemasa Matsufuji
    • 1
  • Keizo Sugimachi
    • 1
  • Kiyoshi Inokuchi
    • 1
  1. 1.Department of Surgery II, Faculty of MedicineKyushu UniversityFukuoka 812Japan

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