Serum CEA levels facilitate detection of recurrences of cancer in patients after gastrectomy
- 24 Downloads
In an attempt to assess the usefulness of carcinoembryonic antigen (CEA) for predicting the progression of gastric cancer, CEA productivity was evaluated according to serum CEA levels, at the time of recurrence or relapse. In cases of a recurrence, abnormal CEA levels were observed in 14 of 17 (82.4 per cent) with differentiated carcinoma and in 9 of 21 (42.9 per cent) with undifferentiated carcinoma. Preoperative abnormal CEA levels were observed in only 6 of 41 patients (14.6 per cent). A median lead time of manifestation of recurrence was 5 months. In those with relapse, 9 of 11 (81.8 per cent) patients with differentiated carcinoma and 13 of 18 (72.2 per cent) with an undifferentiated carcinoma had abnormal CEA levels. Preoperative abnormal CEA levels were observed in 24 of these 89 patients (27.0 per cent). Postoperative monitoring of CEA seems to be useful for early recognition of gastric cancer progression, irrespective of the preoperative CEA levels.
Key Wordscarcinoembryonic antigen gastric cancer recurrence
Unable to display preview. Download preview PDF.
- 2.National Institutes of Health Consensus Development Conference Statement. Carcinoembryonic antigen: Its role as a marker in the management of cancer. Cancer Res 1981; 41: 2017–2018.Google Scholar
- 10.Masaki M, Iizuka Y, Morito T, Murai T, Yoshida H, Igarashi T, Kasukawa R, Gonoi T, Yoshida T. Studies on correlation between tumor carcinoembryonic antigen (CEA) content and plasma CEA level in patients with cancer of the stomach and colon. (Jpn J Gastroenterol) 1978; 75: 1911–1923. (in Japanese)Google Scholar
- 11.Zamcheck N, Doos WG, Prudente R, Lurie BB, Gottlieb LS. Prognostic factors in colon carcinoma. —Correlation of serum carcinoembryonic antigen level and tumor histopathology, Human Pathol 1975; 6: 31–45.Google Scholar
- 14.Denk H, Eckerstorrer R, and Holzner. Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor-cell differentiation. Int J Cancer 1972; 10: 252–272.Google Scholar
- 16.Mori T, Wakumoto H, Shimano T, Lee PK, Higashi H. Immunopathological studies on CEA and CEA-associated antigens with reevaluation of the cancer specificities of CEA. Ann N Y Acad of Sci 1975; 259: 412–416.Google Scholar