Skip to main content
SpringerLink
Log in

A patient with gastric carcinoma improved remarkably on intraperioneal OK-432 therapy

  • Original Articles
  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

A patient with an abdominal tumor and gastric cancer was treated with intraperitoneal OK-432 alone. Her general condition improved and the abdominal mass diminished significantly. The fluoroscopic radiography and gastroduodenal fiberscopic examinations revealed a slight improvement. Four months after the initiation of OK-432 therapy, microscopic examination of the biopsy specimen disclosed degenerated tumor cells with a pronounced accumulation of lymphocytes and large monocytes which were ascertained to be macrophages by the fluorescent antibody technique using anti-macrophage serum. This study revealed one possible mechanism of the antitumor action of OK-432.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baldwin, R.W., Hopper, D.G. and Pimm, M.V.: Bacillus Calmette-Guerin contact immuno-therapy of local and metastatic deposits of rat tumors. International conference on immunotherapy of cancer. Ann. NY Acad. Sci. 227: 124–134, 1976.

    Google Scholar 

  2. Bartlet, G.L., Zbar, B. and Rapp, H.J.: Suppression of murine tumor growth by immune reaction to the Bacillus Calmette-Guerin strain of mycobacterium bovis, J. Nat. Cancer Inst. 48: 245–257, 1972.

    Google Scholar 

  3. Meyer, T.J., Ribi, E.E., Azuna, I. and Zbar, B.: Biologically active components from mycobacterial cell walls. II. Suppression and regression of strain-2 guinea pig hepatoma. J. Nat. Cancer Inst. 52: 103–111, 1974.

    PubMed  CAS  Google Scholar 

  4. Yamamura, Y., Azuma, I., Taniyama, T., Ribi, E. and Zbar, B.: Suppression of tumor growth and regression of established tumor with oil-attached mycobacterial fractions. Gann 65: 179–181, 1974.

    PubMed  CAS  Google Scholar 

  5. Gray, G.R., Ribi, E., Granger, D., Parker, R., Azuma, I. and Yamamoto, K.: Immunotherapy of Cancer: tumor suppression and regression by cell walls of mycobacterium phlei attached to oil droplets. J. Nat. Cancer Inst. 55: 727–730, 1975.

    PubMed  CAS  Google Scholar 

  6. Bast, R.C., Jr., Zbar, B., Miller, T.E., Mackerness, G.B. and Rapp, H.J.: Antitumor activity of bacterial infection. II. Effect of listeria monocytogenes on growth of a guinea pig hepatoma. J. Nat. Cancer Inst. 54: 757–761. 1975.

    PubMed  Google Scholar 

  7. Amiel, J.L., Berardet, M.: An experimental model of active immunotherapy preceded by cytoreductive chemotherapy. Eur. J. Cancer. 6: 557–559, 1970.

    PubMed  CAS  Google Scholar 

  8. Fisher, J.C., Grace, W.R. and Mannick, J.A.: The effect of nonspecific immune stimulation with corynebacterium parvum on patterns of tumor growth. Cancer 26: 1379, 1970.

    Article  PubMed  CAS  Google Scholar 

  9. Pearson, J.W., Pearson, G.R., Gibson, W.T., Chermann, J.C. and Chirigos, M.A.: Combined chemo-immuno-stimulation therapy against murine leukemia, Cancer Res. 32: 904–907, 1972.

    PubMed  CAS  Google Scholar 

  10. Cohen, C. and Tissot, R.G.: The effect of vaccination with B. pertussis on the survival time of leukemic mice. Bacteriol. Proc. 63: 70, 1963.

    Google Scholar 

  11. Veskova, T.K., Chimishkyan, K.L. and Svet-Moldavsky, G.J.: Effect of Brucella abortus infection (Vaccine strain 19BA) on Rauscher leukemia virus and L 1210 leukemia in mice. J. Nat. Cancer Inst. 52: 1651–1653, 1974.

    PubMed  CAS  Google Scholar 

  12. Keller, R., Ogilvie, B.M. and Simpson, E.: Tumor growth in nematode-infected animals. Lancet 1: 678–780, 1971.

    Article  PubMed  Google Scholar 

  13. Okamoto, H., Shoin, S., Koshimura, S. and Shimizu, R.: Studies on the anticancer and streptolysin S-forming abilities of hemolytic streptococci. Jpn. J. Microbiol. 11: 323–336, 1967.

    PubMed  CAS  Google Scholar 

  14. Yamagishi, H., Rellis, N.R. and Kahan, B.D.: Streptococcal immunotherapy of a chemically induced murine fibrosarcoma: Effect of dose, route, sham surgery, and splenectomy on adjuvant action. Cancer Immunol. Immunother. 9: 63–67, 1980.

    Article  Google Scholar 

  15. Yamagishi, H., Tanaka, T., Kodama, M., Iguchi, K., Maeda, Y., Shibata, J. and Hashimoto, I.: Analysis of the histiocytosis in the lymph node using anti-human macrophage serum (AMS). J. Kyoto Pref. Univ. Med. 91: 141–151, 1982.

    Google Scholar 

  16. Oshimi, K., Kano, S., Takaku, F. and Okumura, K.: Augmentation of mouse natural killer cell activity by a streptococcal preparation, OK-432, activity by a streptococcal preparation, OK-432. J. Nat. Cancer Inst. 65: 1265–1269, 1981.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Second Department of Surgery, Kyoto Prefectural University of Medicine, Kamikyo-ku, 602, Kyoto, Japan

    Hisakazu Yamagishi, Haruaki Ishibashi, Masashi Kodama, Tsuguo Tanaka, Yoshihiro Harada & Isamu Hashimoto

Authors
  1. Hisakazu Yamagishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Haruaki Ishibashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masashi Kodama
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tsuguo Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshihiro Harada
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Isamu Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamagishi, H., Ishibashi, H., Kodama, M. et al. A patient with gastric carcinoma improved remarkably on intraperioneal OK-432 therapy. The Japanese Journal of Surgery 12, 434–441 (1982). https://doi.org/10.1007/BF02469834

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02469834

Key Words

Search

Navigation