Abstract
An unusual case of pure red-cell aplasia (PRCA) developed sixteen days after irradiation of an asymptomatic thymoma. After removal of the encapsulated thymoma there was no improvement in the anemia, and no response to adrenocortical and anabolic steroid hormones or immunosuppressive agents.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Humphreys, G.H. and Southworth, H.: Aplastic anemia terminated by removal of a mediastinal tumor. AM. J. Med. Sci. 210: 501–510, 1945.
Jacobs, E.M., Hutter, R.V.P., Pool, J.L. and Ley, A.B.: Benign thymoma and selective erythroid aplasia of the bone marrow. Cancer 12: 47–57, 1959.
Schmid, J.R., Kiely, J.M., Harrison, E.G.Jr., Bayrd, E.D. and Pease, G.L.: Thymoma associated with pure red cell agenesis. Cancer 18: 216–229, 1965.
Zeok, J.V., Todd, E.P., Dillon, M., Desimone, P. and Utley, J.R.: The role of thymectomy in red cell aplasia. Ann. Thorac. Surg. 28: 258–260, 1978.
Robins-Browne, R.M., Green, R., Katz, J. and Becker, D.: Thymoma, pure red cell aplasia, pernicious anemia and candidiasis: a defect in immunohomeostasis. Brit. J. Haemat. 36: 5–13, 1977.
Skikne, B.S., Lynch, S.R., Bezwoda, W.R., Bothwell, T.H., Bernstein, R. and Katz, J.: Pure Red Cell Aplasia. S. Afr. Med. J. 50: 1353–1357, 1976.
Al-Mondhiry, H., Zanjani, E.D., Spivack, M., Zalusky, R. and Gorden, A.S.: Pure red cell aplasia and thymoma: Loss of serum inhibitor of erythropoiesis following thymectomy. Blood 38: 576–582, 1971.
Clarkson, B. and Prockop, D.J.: A regenerative anemia associated with benign thymoma. New Eng. J. Med. 259: 253–258, 1958.
Frøland, S.S., Wisløff, G. and Stavem, P.: Abnormal lymphocyte populations in pure red cell aplasia. Scand. J. Haematol. 17: 241–250, 1976.
Krantz, S.B. and Kao, V.: Studies on red cell aplasia. II. Report of a second patient with an antibody to erythroblast nuclei and a remission after immunosuppressive therapy. Blood 34: 1–13, 1969.
Safdar, S.H., Krantz, S.B., and Brown, E.B.: Successful immunosuppressive treatment of erythroid aplasia appearing after thymectomy. Brit. J. Haemat. 19: 435–443, 1970.
Marmont, A., Peschle, C., Sanguineti, M. and Congotelli, M.: Pure red cell aplasia (PRCA): Response of three patients to Cyclophosphamide and/or Anti-Lymphocyte Globulin (ALG) and demonstration of two types of serum IgG inhibitors to erythropoiesis. Blood 45: 247–261, 1975.
Geary, C.G., Byron, P.R., Taylor, G., Maclver, J.E. and Zervas, J.: Thymoma associated with pure red cell aplasia, immunoglobulin deficiency and an inhibitor of antigen induced lymphocyte transformation. Brit. J. Haemat. 29: 479–485, 1975.
Harvard, C.W.H. and Parrish, J.A.: Thymic tumor and erythroblastic aplasia. J.A.M.A. 179: 228–229, 1962.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shibata, K., Masaoka, A., Mizuno, T. et al. Pure red cell aplasia following irradiation of an asymptomatic thymoma. The Japanese Journal of Surgery 12, 419–423 (1982). https://doi.org/10.1007/BF02469831
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469831