The Japanese journal of surgery

, Volume 15, Issue 2, pp 166–172 | Cite as

Gravimetric, histological and cytotoxic changes of lymphoreticular tissue after implantation of tumor cells in mice

  • Koichiro Morita
  • Hitoshi Mohri
Original Articles


In inbred C3H/He male mice, gravimetric, histologic and cytotoxic changes in the lymphoreticular tissue after implantation of the tumor cells were studied. Gravimetric changes found in the thymus and the spleen suggest that the thymus plays an essential role until death in a tumor-bearing host and that the thymus and the spleen have inverse functions in relation to tumor growth. In this study, no association was found between the large pyroninophilic cells in the deep cortex of the lymph nodes and the cytotoxicity against the tumor cells. However, enlargement of the deep cortex of lymph nodes may be associated with cytotoxicity against these tumor cells.

Key words

lymphoreticular tissue lymphocyte cytotoxicity tumor-bearing mouse cancer immunology 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Scollay RG, Butcher EC, Weissman IL. Thymus cell migration, Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur J Immunol 1980; 10: 210–218.PubMedGoogle Scholar
  2. 2.
    Perez CA, Stewart CC, Palmer-Hanes LA, Powers WE. Role of the regional lymph nodes in the cure of a murine lymphosarcoma. Cancer 1973; 32: 562–572.PubMedCrossRefGoogle Scholar
  3. 3.
    Yamagishi H, Pellis NR, Kahan BD. Effect of splenectomy upon tumor growth: Characterization of splenic tumor-enhancing cells in vivo. Surgery 1980; 87: 655–661.PubMedGoogle Scholar
  4. 4.
    Edwards AJ, Sumner MR, Rowland GF, Hurd CM. Changes in lymphoreticular tissues during growth of a murine adenocarcinoma. 1. Histology and weight of lymph nodes, spleen, and thymus. J Nat Cancer Inst 1971; 47: 301–311.PubMedGoogle Scholar
  5. 5.
    Meyer JD, Meyer JA. Prevention by splenectomy of thymus weight depletion in the presence of progressively growing tumor in rats: Brief communication. J Nat Cancer Inst 1977; 59: 1023–1025.PubMedGoogle Scholar
  6. 6.
    Nelson DS, Kearney R. Macrophages and lymphoid tissues in mice with concomitant tumor immunity. Br J Cancer 1976; 34: 221–226.PubMedGoogle Scholar
  7. 7.
    Von Wallenberg H, Mainusch P, Meyer J, Hammer C. Der Einfluss de Milz auf das Wachstum von Tumoren in Mäuselinien mit unterschiedlicher Milzgröße. Chir Forum Exp Klin Forsch 1979; 169–173.Google Scholar
  8. 8.
    Roberts JG, Chare MJB, Leach KG, Baum M. Spleen size in women with breast cancer. Clin Oncology 1979; 5: 317–323.Google Scholar
  9. 9.
    Woodruff MFA, Symes MO. The significance of splenomegaly in tumor-bearing mice. Br J Cancer 1962; 16: 120–130.PubMedGoogle Scholar
  10. 10.
    Flannery GR, Muller HK, Nairn RC. Lymphoreticular response to a syngeneic rat tumor: Gravimetric and histological studies. Br J Cancer 1975; 31: 614–619.PubMedGoogle Scholar
  11. 11.
    Collste LG, Darzynkiewicz S, Traganos F, Sharpless TK, Whitmore WF, Melamed MR. Regional lymph node reactivity in explanted bladder cancer of mice as measured by flow cytometry. Cancer Res 1979; 39: 2120–2124.PubMedGoogle Scholar
  12. 12.
    Bloom W, Fawcett DW. A textbook of histology. 1975; pp. 427–428, W. B. Saunders, Philadelphia.Google Scholar
  13. 13.
    Jones JA, Robinson G, Rees RC, Baldwin RW. Immune response of the draining and distal lymph nodes during the progressive growth of a chemically-induced transplantable rat hepatoma. Int J Cancer 1978; 21: 171–178.PubMedGoogle Scholar
  14. 14.
    Fisher ER, Fisher B, Saffer E. The regional lymph node in cancer, Relationship of nodal histologic findings to cytotoxicity and immunity. Arch Pathol Lab Med 1977; 101: 152–155.PubMedGoogle Scholar

Copyright information

© The Japan Surgical Society 1985

Authors and Affiliations

  • Koichiro Morita
    • 1
  • Hitoshi Mohri
    • 1
  1. 1.First Department of SurgeryYamaguchi University School of MedicineUbe, YamaguchiJapan

Personalised recommendations