The Japanese journal of surgery

, Volume 15, Issue 2, pp 166–172 | Cite as

Gravimetric, histological and cytotoxic changes of lymphoreticular tissue after implantation of tumor cells in mice

  • Koichiro Morita
  • Hitoshi Mohri
Original Articles
  • 15 Downloads

Abstract

In inbred C3H/He male mice, gravimetric, histologic and cytotoxic changes in the lymphoreticular tissue after implantation of the tumor cells were studied. Gravimetric changes found in the thymus and the spleen suggest that the thymus plays an essential role until death in a tumor-bearing host and that the thymus and the spleen have inverse functions in relation to tumor growth. In this study, no association was found between the large pyroninophilic cells in the deep cortex of the lymph nodes and the cytotoxicity against the tumor cells. However, enlargement of the deep cortex of lymph nodes may be associated with cytotoxicity against these tumor cells.

Key words

lymphoreticular tissue lymphocyte cytotoxicity tumor-bearing mouse cancer immunology 

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Copyright information

© The Japan Surgical Society 1985

Authors and Affiliations

  • Koichiro Morita
    • 1
  • Hitoshi Mohri
    • 1
  1. 1.First Department of SurgeryYamaguchi University School of MedicineUbe, YamaguchiJapan

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