The Japanese journal of surgery

, Volume 14, Issue 4, pp 286–292 | Cite as

Clinical evaluation of schizophyllan adjuvant immunochemotherapy for patients with resectable gastric cancer —A randomized controlled trial—

  • Shigeru Fujimoto
  • Hisashi Furue
  • Tadashi Kimura
  • Tatsuhei Kondo
  • Kunzo Orita
  • Tetsuo Taguchi
  • Koichi Yoshida
  • Nobuya Ogawa
  • SPG Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Gastric Cancer
Original Articles


Adjuvant immunochemotherapy using schizophyllan (SPG), an extract from the culture broth ofSchizophyllum commune Fries, was prescribed at random for 326 Japanese patients with resectable gastric cancer. The overall survival rates for 3 years did not differ between the SPG and control groups. In 62 patients with stage I gastric cancer and 67 with stage II, there was little difference in the 3-year survival rates. The survival rates for 100 patients with stage III were enhanced at p=0.0811 in the SPG group, as compared to the controls. The survival rates in 97 patients with stage IV cancer were much the same. These results warrant further application of this immunopotentiating drug for treating patients with resectable gastric cancer.

Key Words

adjuvant immunochemotherapy Schizophyllan SPG gastric cancer 


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Copyright information

© The Japan Surgical Society 1984

Authors and Affiliations

  • Shigeru Fujimoto
    • 1
  • Hisashi Furue
    • 2
  • Tadashi Kimura
    • 3
  • Tatsuhei Kondo
    • 4
  • Kunzo Orita
    • 5
  • Tetsuo Taguchi
    • 6
  • Koichi Yoshida
    • 7
  • Nobuya Ogawa
    • 8
  • SPG Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Gastric Cancer
  1. 1.The First Department of Surgery, School of MedicineChiba UniversityChibaJapan
  2. 2.Department of Internal MedicineTeikyo UniversityKawasakiJapan
  3. 3.Department of SurgeryNational Medical Center HospitalTokyoJapan
  4. 4.The Second Department of SurgeryNagoya University School of MedicineNagoyaJapan
  5. 5.The First Department of SurgeryOkayama University Medical SchoolOkayamaJapan
  6. 6.Department of Oncologic Surgery, Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan
  7. 7.Department of SurgeryMiyagi Seijinbyo CenterNatoriJapan
  8. 8.Department of Pharmacology, School of MedicineEhime UniversityEhimeJapan

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