Advertisement

The Japanese journal of surgery

, Volume 14, Issue 4, pp 286–292 | Cite as

Clinical evaluation of schizophyllan adjuvant immunochemotherapy for patients with resectable gastric cancer —A randomized controlled trial—

  • Shigeru Fujimoto
  • Hisashi Furue
  • Tadashi Kimura
  • Tatsuhei Kondo
  • Kunzo Orita
  • Tetsuo Taguchi
  • Koichi Yoshida
  • Nobuya Ogawa
  • SPG Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Gastric Cancer
Original Articles

Abstract

Adjuvant immunochemotherapy using schizophyllan (SPG), an extract from the culture broth ofSchizophyllum commune Fries, was prescribed at random for 326 Japanese patients with resectable gastric cancer. The overall survival rates for 3 years did not differ between the SPG and control groups. In 62 patients with stage I gastric cancer and 67 with stage II, there was little difference in the 3-year survival rates. The survival rates for 100 patients with stage III were enhanced at p=0.0811 in the SPG group, as compared to the controls. The survival rates in 97 patients with stage IV cancer were much the same. These results warrant further application of this immunopotentiating drug for treating patients with resectable gastric cancer.

Key Words

adjuvant immunochemotherapy Schizophyllan SPG gastric cancer 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Fujimoto S, Akao T, Itoh B, Kitsukawa Y, Takahashi M, Minami T, Ishigami H, Miyazaki M, Amamiya K, Ohyama Y, Kure M. Protracted oral chemotherapy with fluorinated pyrimidines as an adjuvant to surgical treatment for stomach cancer. Ann Surg 1977; 185: 462–466.PubMedGoogle Scholar
  2. 2.
    Kondo T, Inokuchi K, Hattori T, Inoue K, Taguchi T, Akiyama H, Abe O, Ito I, Nakajima T, Muto T, Kikuchi K, Kasai Y, Sugie S, Hayasaka A. Multi-hospital randomized study on the adjuvant chemotherapy with mitomycin-C and futraful for gastric cancer. V. Estimation of five-year survival rate. Jpn J Cancer Chemother 1982; 9: 2016–2024. (in Japanese)Google Scholar
  3. 3.
    Carter KS, Comis RL. Gastric cancer: Current status of treatment. J Natl Cancer Inst 1977; 58: 567–578.PubMedGoogle Scholar
  4. 4.
    Yamamoto T, Yamashita T, Tsubura E. Inhibition of pulmonary metastasis of Lewis lung carcinoma by a glucan, Schizophyllan. Invasion and Metastasis 1981; 1: 71–84.Google Scholar
  5. 5.
    Komatsu N, Okubo S, Kikumoto K, Kimura K, Saito G, Sakai S. Host-mediated antitumor action of schizophyllan, a glucan produced by Schizophyllum Commune. Gann 1969; 60: 137–144.PubMedGoogle Scholar
  6. 6.
    Mizuhira V, Shiihashi M, Shibuya K, Amamiya K, Hase T. The fate of3H-SPG administered to sarcoma-180 grafted mice. Electron Microscopy 1980; 2: 382–383.Google Scholar
  7. 7.
    Hattori T, Ito I, Hirata K. Large dose administration of mitomycin C during gastrectomy followed by homologous bone marrow transplantation. Gann 1964; 55: 211–224.PubMedGoogle Scholar
  8. 8.
    Japanese Research Society for Gastric Cancer. The General Rules for the Gastric Cancer Study in Surgery and Pathology. Jpn J Surg 1981; 11: 127–139.CrossRefGoogle Scholar
  9. 9.
    Orita K, Mannami T, Miwa H, Ohta T, Nakahara H, Konaga E, Tanaka S. Immunotherapy for advanced gastric cancer and colorectal cancer using BCG cell-wall skelton. Gann Monograph, Cancer Res 1978; 21: 163–171.Google Scholar
  10. 10.
    Hattori T, Niimoto M, Koh T, Nakano A, Oride M, Takiyama W, Nishimawari K. Postoperative long-term immunochemotherapy with mitomycin-C, PSK and FT-207 in gastric cancer. Jpn J Surg 1979; 9: 110–117.PubMedCrossRefGoogle Scholar
  11. 11.
    Fujimoto S, Takahashi M, Minami T, Ishigami H, Miyazaki M, Itoh K. Clinical value of immunochemotherapy with OK-432 or PSK for stomach cancer patients. Jpn J Surg 1979; 9: 190–196.PubMedCrossRefGoogle Scholar
  12. 12.
    Akao T, Fujimoto S, Itoh B, Kitsukawa Y, Takahashi M, Minami T, Ishigami H, Miyazaki M, Itoh K. Fundamental and clinical studies on antitumor polysaccharide. Jpn J Cancer Chemother 1980; 7: 321–326. (in Japanese)Google Scholar
  13. 13.
    Minami T. Immunological studies on patients with gastrointestinal cancer—with particular emphasis on influence of surgery and immunomodulators—. J Jpn Soc Cancer Ther 1981; 16: 1248–1256. (in Japanese)Google Scholar

Copyright information

© The Japan Surgical Society 1984

Authors and Affiliations

  • Shigeru Fujimoto
    • 1
  • Hisashi Furue
    • 2
  • Tadashi Kimura
    • 3
  • Tatsuhei Kondo
    • 4
  • Kunzo Orita
    • 5
  • Tetsuo Taguchi
    • 6
  • Koichi Yoshida
    • 7
  • Nobuya Ogawa
    • 8
  • SPG Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Gastric Cancer
  1. 1.The First Department of Surgery, School of MedicineChiba UniversityChibaJapan
  2. 2.Department of Internal MedicineTeikyo UniversityKawasakiJapan
  3. 3.Department of SurgeryNational Medical Center HospitalTokyoJapan
  4. 4.The Second Department of SurgeryNagoya University School of MedicineNagoyaJapan
  5. 5.The First Department of SurgeryOkayama University Medical SchoolOkayamaJapan
  6. 6.Department of Oncologic Surgery, Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan
  7. 7.Department of SurgeryMiyagi Seijinbyo CenterNatoriJapan
  8. 8.Department of Pharmacology, School of MedicineEhime UniversityEhimeJapan

Personalised recommendations