The Japanese journal of surgery

, Volume 12, Issue 5, pp 372–380 | Cite as

Superior action of magnesium-lidocaine-1-aspartate cardioplegia to glucose-insulin-potassium cardioplegia in experimental myocardial protection

  • Makoto Sunamori
  • Jun Amano
  • Takao Okamura
  • Akio Suzuki
Original Articles


The effect of 2 hours of hypothermic Mg-lidocaine cardioplegia upon left ventricular function, myocardial high-energy stores, edema, and ultrastructure was studied as compared to glucose-insulin-potassium (GIK) cardioplegia in 12 mongrel dogs. The myocardial temperature recorded in the ventricular septum was kept at 20°C during the cardioplegia. The heart was re-warmed up to 37°C by the support of cardiopulmonary bypass, then, observations were made during a 60 minutes reperfusion. Left ventricular function was preserved at a more physiological level in cases of Mg-lidocaine cardioplegia. Myocardial ATP was preserved at significantly higher levels following Mg-lidocaine cardioplegia than in cases of GIK cardioplegia (p<0.05). However, content of myocardial creatine phosphate was higher in the GIK cardioplegia group than that in Mg-lidocaine group in the subendocardium and the ventricular septum. Myocardial edema was significantly suppressed following Mg-lidocaine cardioplegia, and such was significantly lower than in cases of GIK cardioplegia (p<0.05). The myocardial ultrastructure was protected from ischemic insult in the Mg-lidocaine cardioplegia group. These data suggest that Mg-lidocaine-1-aspartate solution is superior to GIK solution as a cardioplegic solution, and that such will feasibly provide myocardial, protection for 2 hours of hypothermic cardiac arrest, in an experimental reperfused model.

Key Words

cardioplegia myocardial protection lidocaine hypothermia 


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Copyright information

© The Japan Surgical Society 1982

Authors and Affiliations

  • Makoto Sunamori
    • 1
  • Jun Amano
    • 1
  • Takao Okamura
    • 1
  • Akio Suzuki
    • 1
  1. 1.Department of Thoracic-Cardiovascular SurgeryJuntendo University School of MedicineTokyoJapan

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