Abstract
The caecal apex in rats was ligated and animals given no treatment died at an early period. When kanamycin intraperitoneally (i.p.) or kanamycin i.p. plus heparin 20 units subcutaneously (s.c.) were given, 75 per cent of rats died within 10 days after development of peritonitis. In rats given kanamycin and heparin i.p., 25 per cent of rats died at much the same time. On the contrary, survival rates were 100 per cent in rats treated with kanamycin and heparin i.p. and heparin s.c. (total dose of heparin was same as given to other groups). In these rats, bacteria were not cultured from the fluid obtained in the peritoneal cavity. These results suggest that when heparin is given i.p. or s.c., it plays a significant role as an adjuvant in the treatment of peritonitis along with the usual chemotherapy.
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References
Stephen, M. and Lowenthal, J.: Generalised infective peritonitis. Surg. Gynecol. Obstet. 147: 231–234, 1978.
Rains, A. J. H. and Ritchie, H. D.: Bailey and Love's Short Practice of Surgery, 18th Ed. pp. 966–981, Lewis, London, 1982.
Schwartz, S. I.; Shires, G.T.; Spencer, F.C. and Storer, E. H.: Principles of Surgery, 3rd Ed. pp. 1397–1423, McGraw Hill, New York, 1979.
Anderson, W.: Boyd's Pathology for Surgeons, 8th Ed. pp. 337–348, Kothari, Book Depot, Bombay, 1969.
Hau, T. and Simmons, R. L.: Heparin in the treatment of experimental peritonitis. Ann. Surg. 187: 294–298, 1978.
Hau, T.; Payne, W. D. and Simmons, R. L.: Fibrinolytic activity of the peritoneum during experimental peritonitis. Surg. Gynecol. Obstet. 148: 415–418, 1979.
Davidson, R. K.; Cardenas, A. and Busuttil, R. W.: The effects of heparin and low molecular weight dextran on survival after fibrino-purulent peritonitis. Surg. Gynecol. Obstet. 193: 327–331, 1981.
O'Leary, J. P.; Malik, F. S.; Donahoe, R. R. and Johnston, A. D.: The effects of minidoses of heparin in peritonitis in rats. Surg. Gynecol. Obstet. 148: 571–575, 1979.
Zinsser, H. H. and Pryde, A. W.: Experimental study of physical factors including fibrin formation influencing the the spread of fluids and small particles within and from peritoneal cavity of dogs. Ann. Surg. 131: 818–822, 1952.
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Mohan Bagree, M., Kumar Aneja, R. Adjuvant effect of heparin on peritonitis induced in rats. The Japanese Journal of Surgery 13, 546–548 (1983). https://doi.org/10.1007/BF02469502
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DOI: https://doi.org/10.1007/BF02469502