Abstract
Experimental ischemic colitis was produced in 42 dogs by either ligation (ligation group, n=18) or temporary occlusion of the mesenteric vessels (temporary occlusion group, n=24) and changes in the local blood flow in the bowel were measured by the hydrogen clearance method. Tissue damage similar to damage seen in patients with ischemic colitis were produced in both of these groups. There was a close correlation between the severity of the ischemia and the ensuing tissue damages. In the ligation group, the tissue damages ranging from erosions or minute ulcerations to diffuse ulcerations occurred when the local blood flow was measured at 30 minutes after the ligation and was below 50 per cent of the basal flow. In the temporary occlusion group, the tissue damages were observed when the local blood flow was below 40 per cent of the basal flow and the occlusion was maintained for over two hours.
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References
Boley, S. J., Schwartz, S., Lash, J. and Sternhill, V.: Reversible vascular occlusion of the colon. Surg. Gynecol. Obstet. 116: 53–60, 1963.
Marston, A., Pheils, M. T., Thomas, M. L. and Morson, B. C.: Ischemic colitis. Gut 7: 1–15, 1966.
Griffen, T. S. and Hagihara, P. F.: Ischemic colitis in rats. Dis. Colon Rectum 25: 638–640, 1982.
Mishima, Y. and Horie, Y.: Experimental studies of ischemic enterocolitis. World J. Surg. 4: 601–608, 1980.
Schwartz, S., Boley, S., Lash, J. and Sternhill, V.: Roentogenologic aspects of reversible vascular occlusion of the colon and its relationship to ulcerative colitis. Radiology 80: 625–635, 1963.
Wittenberg, J., Athanasoulis, C. A., Williams, L. F. Jr., Paredes, S., O'Sullivan, P. and Brown, B.: Ischemic colitis: Radiology and pathophysiology. Amer. J. roentogenol. 123: 287–300, 1975.
Aukland, K., Bower, B. F. and Berliner, R. W.: Measurement of local blood flow with hydrogen gas. Circulation 14: 164–187, 1979.
Mishima, Y., Shigematsu, H., Horie, Y. and Satoh, M.: Measurement of local blood flow of the intestine by hydrogen clerance method; Experimental study. Jpn. J. Surg. 9: 63–70, 1979.
Delaney, J. P.: Chronic alterations in gastrointestinal blood flow induced by vagotomy. Surgery 62: 155–157, 1967.
Hagihara, P. F., Ernst, C. B. and Griffen, W. O. Jr.: Incidence of ischemic colitis following abdominal aortic reconstruction. Surg. Gynecol. Obstet. 149: 571–573, 1979.
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Suzuki, H., Kato, T., Iriyama, K. et al. Experimental ischemic colitis in dogs. The Japanese Journal of Surgery 13, 530–534 (1983). https://doi.org/10.1007/BF02469498
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DOI: https://doi.org/10.1007/BF02469498