Skip to main content
Log in

Malignant thymoma associated with liposarcoma of the mediastinum —A case report—

  • Original Articles
  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

Malignant thymoma occurring concurrently with mediastinal liposarcoma in a 49-year-old man is described. The patient underwent an incomplete resection of the mediastinal mass followed by irradiation therapy and additional chemotherapy. He died about 9 months after the detection of a mediastinal mass on chest X-ray films and the immediate cause of death was superior vena cava syndrome. The incidence of primary liposarcoma of the mediastinum alone is extremely rare. Only a few more than 20 with such a lesion have been docummented in Japan. A review of the literature of patients with mediastinal liposacoma and thymoma associated with malignancies revealed no case of an association of thymoma and liposacoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Souadjian, J. V., Enriquez, P., Silverstein, M. N., and Pepin, J.: The spectrum of diseases associated with thymoma. Coincidence or syndrome? Arc. Intern. Med. 134: 374–379, 1974.

    Article  CAS  Google Scholar 

  2. Souadjian, J. V., Silverstein, M. N., and Titus, J. L.: Thymoma and cancer. Cancer 22: 1221–1225, 1968.

    Article  PubMed  CAS  Google Scholar 

  3. Lattes, R.: Thymoma and other tumors of the thymus. Cancer 15: 1224–1260, 1962.

    Article  Google Scholar 

  4. Vessy, M. P. and Doll, R.: Thymectomy and cancer-a follow up study. Br. J. Cancer 26: 53–58, 1972.

    Google Scholar 

  5. Jain, U. and Frable, W. J.: Thymoma. Analysis of benign and malignant criteria. J. Thorac. Cardiovasc. Surg. 67: 310–321, 1974.

    PubMed  CAS  Google Scholar 

  6. Castleman, B. (Ed.): Case records of the Massachusetts General Hospital. Case 14-1962. New Eng. J. Med. 266: 458–465, 1962.

  7. Gould, J. S., Tanguay, P. R., and De Lellis, R. A.: Thymoma and primary lymphoma of the small intestine. Cancer 40: 1755–1758, 1977.

    Article  PubMed  CAS  Google Scholar 

  8. Knowles, D. M., II.: Thymoma and chronic myelogenous leukemia. A case report. Cancer 38: 1414–1419, 1976.

    Article  PubMed  Google Scholar 

  9. Lindstrom, F. D., Williams, R. C., Jr., and Brunning, R. D.: Thymoma associated with multiple myeloma. Arch. Intern, Med. 122: 526–531, 1968.

    Article  CAS  Google Scholar 

  10. Schweizer, D. L. and Aguam, A. S.: Primary liposarcoma of the mediastinum. Report of a case and review of the literature. J. Thorac. Cardiovasc. Surg. 74: 83–97, 1977.

    Google Scholar 

  11. Connors, J. P.: Intrathoracic cancer in clinical oncology, 2nd ed, Horton, J. and Hill, G., Eds, pp. 375, Philadelphia, W. B. Saunders, 1977.

    Google Scholar 

  12. Wada, H. and Teramatsu, T.: Mediastinal tumors-a statistical nationwide report of 1,546 cases between July, 1975 and May, 1979 in Japan Nihon Kyobugeka Gakukai Zasshi (Jpn. J. Thorac, Surg.) 30: 374–378, 1982. (English abst.)

    CAS  Google Scholar 

  13. Nickels, J. and Franssilia, K.: Thymoma metasstasizing to extra-thoracic sites. A case report. Acta Path. Microbiol. Scand. 84: 331–334, 1976.

    CAS  Google Scholar 

  14. Hietala, S. O., Hazra, T. A., and Texter, J. H., Jr.: Malignant thymoma with renal metastases. Report of a case. Acta Radiol. Diag. 19: 337–342, 1978.

    CAS  Google Scholar 

  15. Campbell, M. G., Polland, R., and Al-Sarraf, M.: A complete response in metastic malignant thymoma to cis-platinum, Doxorubicin and Cyclophosphamide: A case report. Cancer 48: 1315–1317, 1981.

    Article  PubMed  CAS  Google Scholar 

  16. Needles, B., Kemeny, N., and Uramacher, C.: Malignant thymoma: Renal metastases responding to Cis-platinum. Cancer 48: 223–226, 1981.

    Article  PubMed  CAS  Google Scholar 

  17. Guillan, R., Zelman, S., Smalley, R., and Iglesias, P.: Malignant thymoma associated with myasthenia gravis and evidence of extra-thoracic metastases. Cancer 27: 823–830, 1971.

    Article  PubMed  CAS  Google Scholar 

  18. Grvanis, M. B.: Metastasizing thymoma. Report of a case and review of the literature. Am. J. Clin. Path. 49: 690–696, 1968.

    Google Scholar 

  19. Rachmaninoff, N. and Fentress, V.: Thymoma with metastases to the brain. Am. J. Clin. Path. 41: 618–625, 1964.

    PubMed  CAS  Google Scholar 

  20. Kubo, K. and Namikawa, S.: Treatment of malignant mediastinal tumor. Nihon Kyobugeka Gakkai Zasshi (Jpn. J. Thorac. Surg.) 19: 77–89, 1971. (English abst.)

    Google Scholar 

  21. Tanaka, S., Omoto, T., Tanizaki, M., Seo, T., Motohiro, K., Mandai, N., and Teramoto, S.: Results of the treatment of thymoma; Clinicopathological study on 43 cases. Nihon Kyobugeka Gakukai Zasshi (Jpn. J. Thorac. Surg.) 26: 1039–1046, 1978 (English abst.)

    CAS  Google Scholar 

  22. Ishikawa, S., Komatsu, K., and Tomiki, K.: Thymoma: Investigation of benign and malignant-related criteria. Nihon Kyobugeka Gakkai Zasshi (Jpn. J. Thorac, Surg.) 24: 1602–1613, 1978. (English Abst.)

    Google Scholar 

  23. Marks, R. D., Jr., Wallace, K. M., and Pettit, H. S.: Radiation therapy control of nine patients with malignant thymoma. Cancer 41: 117–119, 1978.

    Article  PubMed  Google Scholar 

  24. Boston, B.: chemotherapy of invasive thymoma. Cancer 38: 49–52, 1976.

    Article  PubMed  CAS  Google Scholar 

  25. Cicciarelli, F. E., Soule, E. H., and McGoon, D. C.: Lipoma and liposarcoma of the mediastinum: A report of 14 tumors including one lipoma of the thymus. J. Thorac. Cardiovasc. Surg. 47: 411–429, 1964.

    PubMed  CAS  Google Scholar 

  26. Pack, G. T. and Pierson, J. C.: Liposarcoma: A study of 105 cases. Surgery 36: 687–712, 1954.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Okumori, M., Mabuchi, M. & Nakagawa, M. Malignant thymoma associated with liposarcoma of the mediastinum —A case report—. The Japanese Journal of Surgery 13, 512–518 (1983). https://doi.org/10.1007/BF02469495

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02469495

Key Words

Navigation