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Effects of levamisole in adjuvant immunochemotherapy for gastric cancer; A prospective randomized controlled study

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Abstract

The effectiveness of Levamisole combined with Mitomycin-C, FT-207 and PS-K for treating gastric cancer was investigated in a prospective randomized controlled study. All patients had undergone gastrectomy during the years from August 1977 to November 1980. Five year survival rates reveled no difference between groups given or not given Levamisole. In those with positive lymphode metastases plus obvious serosal invasion, there was a significant elevation in the survival rate at four years after gastrectomy. The effectiveness of Levamisole was confirmed by postoperative changes in the PPD skin test, lymphocyte blastogenesis to PHA and serum inhibition index.

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Authors and Affiliations

  1. Research Institute for Nuclear Medicine and Biology, Hiroshima University, Kasumi, Minami-ku, 734, Hiroshima, Japan

    Takao Hattori, Minoru Niimoto, Tetsuya Toge, Mitsutoshi Oride, Akira Nakao & Ken Yoshinaka

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  1. Takao Hattori
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  2. Minoru Niimoto
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  3. Tetsuya Toge
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  4. Mitsutoshi Oride
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  5. Akira Nakao
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  6. Ken Yoshinaka
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Hattori, T., Niimoto, M., Toge, T. et al. Effects of levamisole in adjuvant immunochemotherapy for gastric cancer; A prospective randomized controlled study. The Japanese Journal of Surgery 13, 480–485 (1983). https://doi.org/10.1007/BF02469490

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  • DOI: https://doi.org/10.1007/BF02469490

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