Skip to main content
Log in

Difficulty in blood typing after infusion of plasma substitutes

Relationship to erythrocyte sedimentation rate and rouleaux-formation

  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

Recently we experienced one incident that the patient with A blood type reacted as AB type on macroscopic observation when the blood type was tested immediatly after the infusion with Dextran70 in saline. The patient was confirmed as having the A type by reexamination later. Subsequently 90 cases were subjected to blood typing following infusion with one of the seven plasma substitutes such as dextran, MF-gelatin and HE-starch. One patient demonstrated an abnormal reaction. She had marked acceleration of erythrocyte sedimentation rate (E.S.R.) and positive serological reactions for syphilis before the infusion with Dextran70. It was thought that the rapid increase in high molecular colloids in circulation accelerated rouleaux formation and caused the change in agglutination thus resulted in misjudgement of blood typing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Knoefel, P. K., and Lehmann, G.: Behavior in body of some fractions of gelatin. J. Pharmacol. & Exper. Therap. 83: 185–194, 1945.

    CAS  Google Scholar 

  2. Smith, A.: Plasma volume expanders and blood typing, J.A.M.A. 154: 1398–1399, 1954.

    Google Scholar 

  3. Böhmert, F., and München, I.: Schock Bekämpfung mit einen neuartigen Plasma Expander, Chirurg 34: 228–232, 1963.

    PubMed  Google Scholar 

  4. Bull, J. P., Ricketts, C., Squire, J. R., Maycock, W. D'A., Spooner, S. J. L., Mollison, P. L., and Paterson, J. C. S.: Dextran as a plasma substitute, Lancet I: 134–143, 1949.

    Article  Google Scholar 

  5. Marson, N.: Cross-matching of blood in the presence of dextran, Lancet II: 688–689, 1954.

    Article  Google Scholar 

  6. Wallace, J.: Cross-matching of blood in the presence of dextran, Lancet II: 761–762, 1954.

    Article  Google Scholar 

  7. Inokuchi, K.: Colloid chemical study on sodium alginate as a plasma substitute VI, agglomerating action of sodium alginate on red cells. Memoirs of Faculty of Science, Kyushu University, Ser. C, 1: 167–177 1950.

    CAS  Google Scholar 

  8. Arndt-Hanser, A.: Serologische Untersuchungen nach Dextran Infusion. Bibl. haemat. fasc. 5: 181–185, 1956.

    CAS  Google Scholar 

  9. Freuchen, I., Trostmann, A., and Oslergaads, J.: Haemaccel-a new plasma substitute, Acta. anaesth. Scand. Suppl. 15: 147–149, 1964.

    Article  Google Scholar 

  10. Graf, H., Riemann, S., Spielmann, W., and Wagner, W.: Therapeutische und serologische Erfahrungen mit einem Plasma expander auf Polypeptidbasis (Haemaccel), Münch med. Wschr. 105: 725–729, 1963.

    PubMed  CAS  Google Scholar 

  11. Peters, A., Streiff, F., Genetet, B., and Larcan, A.: Blood groups and plasma substitutes (Dextran and Plasmagel), Bibl. haemat. 33: 338–341, 1969.

    PubMed  CAS  Google Scholar 

  12. Pettenkofer, H. J.: Zur Blutgruppen-bestimmung nach Verabreichung von kolloidalen Plasmaersatzmitteln, Chirurg 30: 25–26, 1959.

    PubMed  CAS  Google Scholar 

  13. Roche, P. Jr., Dolelin, R. A. and Bloom, W.: Effect of dextran on blood typing and cross-matching, Blood 7: 373–375, 1952.

    PubMed  Google Scholar 

  14. Turner, F. P., Butler, B. C., Smith, M. E. and Scudder, J.: Dextran, an experimental plasma substitute, J. Surg. Gynec. & Obst. 88: 661–675, 1949.

    Google Scholar 

  15. Thorsen, G., and Hint, H.: Aggregation, sedimentation and intravascular sludging of erythrocytes, Interrelation between suspension stability and colloid in suspension fluids, An experimental study, Acta. chir. Scand. suppl. 154: 1–50, 1950.

    Google Scholar 

  16. Goto, Y., Aochi, O.: The rheological effects of plasma expanders upon red blood cells, Nagoya Med. J. 18: 253–275, 1973.

    CAS  Google Scholar 

  17. Goto, Y., Aochi, O.: Electrophoresis of red blood cells using U-tube method and influence of plasma substitutes, Asian med. J. 17: 125–133, 1974.

    Google Scholar 

  18. Koop, C. E.: The use of specially prepared gelatin solution as a plasma substitute, surg. Amer. 1300–1315, 1944.

  19. Koop, C. E., and Bullit, L.: Gelatin as a plasma substitute, the effect of gelatin infusion on the subsequent typing and cross-matching of the blood, with a method of eliminating the phenomenon of pseudoagglutination, Amer. J. med. Sci. 209: 28–33, 1945.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goto, Y. Difficulty in blood typing after infusion of plasma substitutes. The Japanese Journal of Surgery 4, 216–221 (1974). https://doi.org/10.1007/BF02469455

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02469455

Key Words

Navigation