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Halothane hepatitis with renal failure treated with hemodialysis and exchange transfusion

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Abstract

A 38-year-old white female, hepatitis B antigen negative, developed fluminating hepatic failure associated with oliguria and severe azotemia after two halothane anesthesia and without exposure to other hepatotoxic drugs or blood transfusions. She was treated with multiple hemodialysis and exchange blood transfusion. The combined treatment corrected the uremic abnormalities and improved her level of consciousness. The liver and kidney function gradually improved, and she made a complete recovery, the first recorded with hepatic and renal failure under these post-anesthetic conditions. Further evaluation of this combined treatment used for this patient is warranted.

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Author notes

  1. Thomas E. Starzl

    Present address: Department of Surgery, University of Colorado Medical Center, 4200 East Ninth Avenue, 80220, Denver, Colorado, USA

Authors and Affiliations

  1. Department of Medicine, University of Colorado Medical Center, Denver, Colorado, USA

    Makoto Ishikawa, Mordecai M. Popovtzer, Shunzaburo Iwatsuki, Torben Johansen & Thomas E. Starzl

  2. Denver Veterans Administration Hospital, Denver, Colorado, USA

    Makoto Ishikawa, Mordecai M. Popovtzer, Shunzaburo Iwatsuki, Torben Johansen & Thomas E. Starzl

  3. Department of Surgery, University of Colorado Medical Center, 4200 East Ninth Avenue, 80220, Denver, Colorado, USA

    Makoto Ishikawa, Mordecai M. Popovtzer, Shunzaburo Iwatsuki & Torben Johansen

Authors
  1. Makoto Ishikawa
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  2. Mordecai M. Popovtzer
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  3. Shunzaburo Iwatsuki
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  4. Torben Johansen
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  5. Thomas E. Starzl
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Additional information

Supported by grants from the Veterans Administration; by grants RR-00051 and RR-00069 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health; and by grants AM-07772 and AI-AM-08898 of the United States Public Health Service.

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Ishikawa, M., Popovtzer, M.M., Iwatsuki, S. et al. Halothane hepatitis with renal failure treated with hemodialysis and exchange transfusion. The Japanese Journal of Surgery 4, 212–215 (1974). https://doi.org/10.1007/BF02469454

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  • DOI: https://doi.org/10.1007/BF02469454

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