Abstract
Sixty three cancer cases who received minimum of the removal of the main tumor constitute the subjects of the present study. Macrophage migration inhibitory factor (MIF) of peripheral blood lymphocytes was studied using extirpated autochthonous tumor tissues as antigen and guinea-pig peritoneal exudative cells as indicator cells immediately before the operation and the fourth postoperative week. The results indicated that in those cases of relatively early stage, i.e. Stages I and II, whose tumor was believed to have been removed completely, MIF turned negative in 7/9 (77.8 per cent) after the operation, while in others with advanced cancer of Stage IV in which the tumor bearing tissue was probably not completely removed, MIF turned positive in most cases (13/17: 75.6 per cent) postoperatively, even though it was negative before the operation. In the cases of Stage III with cancer progressed to an intermediate degree, in about half of the cases (7/11: 63.6 per cent) MIF turned negative after the operation and in the other half (7/10: 70 per cent) MIF became positive postoperatively, suggesting that for MIF to persist the presence of certain amount of tumor tissue is necessary.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andersen, V., Bjerrum, O., Bendixin, G., Schiodt, T. and Dissing, I.: Effects of autologous mammary tumor extracts on human leucocyte migration in vitro,Int. J. Cancer 5: 357–363, 1970.
Cochran, A.J., Spilg, W.G.S., Mackie, R.M. and Thoma, C.E.: Postoperative depression of tumor-directed cell-mediated immunity in patients with malignant disease,Brit. Med. J. 4: 60–70, 1972.
Eilber, F.R. and Morton, D.C.: Impaired immunologic reactivity and recurrence following cancer surgery,Cancer 25: 362–367, 1970.
Eilber, F.R., Morton, D.C., and Ketcham, A.S.: Immunologic abnormalities in head and cancer,Am. J. Surgery 128: 534–538, 1974.
George, M. and Vaughan, J.H.: In vitro cell migration as a model for delayed hypersensitivity,Proc. Soc. Exp. Biol. Med. 111: 514–521, 1962.
Gershon, R.K., Carter, R.L. and Kondo, K.: Immunologic defense against metastases: Impairment by excision of an allotransplanted lymphoma,Science 159: 646–648, 1968.
Greene, H.S.N. and Harvey, E.K.: The inhibitory influence of a transplanted hamster lymphoma on metastasis,Cancer Res. 20: 1094–1100, 1960.
Hellström, I., Hellström, K.E., Sjögren, H.D. and Warner, G.A.: Demonstration of cell-mediated immunity to human neoplasms of various histological types,Int. J. Cancer 7: 1–16, 1971.
Japanese Research Society for Gastric Cancer: The general rules for the gastric cancer study in surgery,Jap. J. Surgery 3: 61–71, 1973.
Lamb, D., Pilney, T., Kelly, W.D. and Good, R.A.: A comparative study of the incidence of energy in patients with carcinoma, leukemia, Hodgkin's disease and lymphomas,J. Immunol. 89: 555–558, 1962.
Lurie, B.B., Bull, D.M., Zamcheck, N., Steward, A.B. and Helms, R.A.: Diagnosis and prognosis in colon cancer based on a profile of immune reactivity,J. Natl. Cancer Inst. 54: 319–325, 1975.
Milas, L., Hunter, N., Mason, K. and Wither, H.R.: Immunological resistance to pulmonary metastases in C3Hf/Bu mice bearing syngeneic fibrosarcoma of different sizes,Cancer Res. 34: 61–71, 1974.
Miller, D.G.: The association of immune disease and malignant lymphomas,Ann. Intern. Med. 66: 507–521, 1967.
Miwa, K.: Clinical use and analysis of registry of gastric cancer patients,J. Jap. Soc. Cancer Ther. 10: 12–13, 1975 (in Japanese).
Ohsugi, M.: Antitumor activity of lymphoid cells from spontaneous mammary tumor-bearing mice on the autochthonous primary culture tumor cells,Acta Med. Okayama 25: 229–235, 1971.
Orita, K.: Reactions of lymphoid cells on target cells in vitro,Acta Haem. Jap. 31: 697–709, 1968.
Orita, K., Kobayashi, M., Konaga, E., Kokumai, Y., Hiramatsu, M. and Tanaka, S.: Growth-inhibition effect of lymph-node cells from cancer patients on autochthonous cell,Acta Med. Okayama 27: 133–140, 1973.
Orita, K., Miwa, H., Ogawa, K., Suzuki, K., Sakagami, K., Konaga, E., Kokumai, Y. and Tanaka, S.: Reduction of immunological surveillance level in cancer patients,Gann Monograph on Cancer Res. 16: 53–62, 1974.
Orita, K., Kobayashi, M., Uchida, Y., Yumura, M., Yamamoto, T., Fukuda, H., Kaneda, S., Mannami, T., Kokumai, Y. and Tanaka, S.: Reduction of concomitant cell-mediated immunity level in advanced cancer patients,Gann Monograph on Cancer Res. 16: 141–152, 1974.
Orita, K., Miwa, H., Fukuda, H., Yumura, M., Uchida, Y., Mannami, T., Konaga, E. and Tanaka, S.: Preoperative cell-mediated immune status of gastric cancer patients,Cancer 38: 2343–2348, 1976.
O'Toole, C., Perlmann, P., Unsgaard, B., Almgard, L.E., Ohanson, B., Moberger, G. and Dsmyr, F.: Cellular immunity to human urinary carcinoma. II. Effect of surgery and preoperative irradiation,Int. J. Cancer 10: 92–98, 1972.
O'Toole, C. and Unsgaard, B.: Cellular immunity to carcinoma of the urinary bladder: Clinical correlations of the response:XI International Cancer Congress Florence, abstracts 3: 391, 1974.
Reed, D.M.: On the pathological changes in Hodgkin's disease with especial reference to its relation to tuberculosis,Johns Hopkins Hosp. Res. 10: 133–198, 1902.
Author information
Authors and Affiliations
Additional information
Supported by Grant No. 077230 in Aid for Scientific Research from the Ministry of Education of Japan.
Rights and permissions
About this article
Cite this article
Orita, K., Mannami, T., Yumura, M. et al. Change of macrophage migration inhibitory factor: Possible indicator for postoperative prognosis. The Japanese Journal of Surgery 7, 118–122 (1977). https://doi.org/10.1007/BF02469341
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469341