Blood gas transport of fluorocarbon emulsion and its effect on the metabolism in peripheral tissue
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In spite of the extensive studies on fluorocarbon (FC) emulsion, the peripheral tissue metabolism and its effect on the acid-base balance in blood have not been reported. The present study was undertaken to study change in blood gas and pH, carbon dioxide output and liver mitochondrial function when FC emulsion was substituted for blood. The improvement of hypoxia and acidosis in animals with massive hemorrhage after exchange infusion of FC emulsion suggest good oxygen carrying capacity of FC emulsion in vivo. The increased carbon dioxide elimination and well preserved pH and PCO2 during FC infusion also indicate efficient transport by FC emulsion of carbon dioxide produced in the peripheral tissue. The excellent maintenance of the respiratory control ratio and P/O ratio of liver mitochondria in rats, when the blood is exchanged with FC emulsion, suggests that improved oxygenation by FC emulsion prevents the appearance of uncoupling substances.
The function of isolated mitochondria in the reaction medium containing FC emulsion showed that the mitochondria were not damaged by FC emulsion itself and could well utilize oxygen contained in the FC emulsion.
Key Wordsfluorocarbon emulsion blood gas transport mitochondrial function artificial blood gas transporter
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