Abstract
In the present study the role of antigen-antitissue antibody complex in causing tissue damage leading to systemic disease has been investigated using immunohistological methods. The membrane, structure of microsomal fraction is considered immunologically quite complex i.e., consisting of a number of antigenically different molecules and hence only few of those molecules can be histocompatible, and tissue specific.
Immune complex nephritis, amyloid deposition and systemic vasculitis up to fibrinoid degeneration of small arteries were successfully induced by prolonged sensitization with immune complex prepared by using a soluble microsomal fraction of lungs from allogenic mice as antigen. The similar changes but in lesser degree and frequency could be induced in mice when injected with antigen in high concentration with Freund’s complete adjuvant in a prolonged period. This suggest that immune complexes formed from the subcellular component in the graft during a course of its decaying process can cause severe tissue damage in the recipient after transplantation.
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Saito, K. Importance of immune complex in transplantation. The Japanese Journal of Surgery 2, 11–20 (1972). https://doi.org/10.1007/BF02468902
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DOI: https://doi.org/10.1007/BF02468902