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The Japanese journal of surgery

, Volume 11, Issue 2, pp 115–123 | Cite as

Lipid metabolism in partially hepatectomized dogs and effect of hepatic periarterial neurectomy

  • Nobuo Mochinaga
Article

Abstract

Lipid metabolism in partially hepatectomized dogs was studied, by observing changes in serum lipids after hepatectomy and biosynthesis of lipids in the slices of the regenerating liver tissue. In addition, the effect of hepatic periarterial neurectomy was evaluated. Serum lipids decreased after partial hepatectomy and did not return to the preoperative level until the first postoperative week, whereas biosynthesis of lipids in the slices of the regenerating liver tissue was considerably augmented in the early postoperative period. This augmentation of lipid synthesis appears to be requirement for regeneration of the liver. When hepatic periarterial neurectomy plus partial hepatectomy was carried out, each lipid and lipoprotein fraction, except for FFA, showed a tendency to recover earlier from the immediate postoperative decrease and did not not show a late postoperative excessive increase. The decrease of α-lipoprotein in the immediate postoperative period was augmented and the time of the peak of concentration of pre-β-lipoprotein was hastened. Therefore, hepatic periarterial neurectomy seems to act in such a manner so as to maintain the homeostasis in lipid metabolism after partial hepatectomy and to activate the regenerative property of the residual liver in the early postoperative period.

Key Words

hepatectomy hepatic periarterial neurectomy regeneration homeostasis lipoprotein phosphoglyceride neutral glyceride 

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Copyright information

© The Japan Surgical Society 1981

Authors and Affiliations

  • Nobuo Mochinaga
    • 1
  1. 1.Second Department of SurgeryNagasaki University School of MedicineNagasakiJapan

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