Abstract
Gastrointestinal disorders often occur during systemic chemotherapy. In an attempt to prevent these side-effects, ursodeoxycholic acid was administered during the systemic chemotherapy. This compound significantly alleviated the side-effects, as assessed by an increase in appetite, total serum protein level and body weight. However, in patients with a deficiency in pancreatic exocrine secretion and/or obstructive jaundice due to metastasis to common bile duct, the effects were nil.
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Bedi, B.S., Debas, H.T., Gillespie, G. and Gillespie, I.E.: Effect of bile salts on antral gastrin release, Gastroenterology 60: 256–262, 1971.
De Jager, R.L., Magill, G.B., Golbey, R.B. and Krakoff, I.H.: Combination chemotherapy with Mitomycin C, 5-Fluorouracil, and Cytosine Arabinoside in gastrointestinal cancer, Cancer Treat. Rep. 60: 1373–1375, 1976.
Forell, M.M., Otte, M., Kohl, H.J., Lehnert, P. and Stahoheber, H.P.: The influence of bile and pure bile salts on pancreatic secretion in man, Scand. J. Gastroenterol. 6: 261–265, 1971.
Guarino, A.M.: Toxicology of anticancer drugs, National Cancer Inst. Monograph 45: 49–55, 1977.
Konturek, S.J. and Thor, P.: Effect of diversion and replacement of bile on pancreatic secretion, Amer. J. Dig. Dis. 18: 971–977, 1973.
Mosbach, E.H.: Hepatic synthesis of bile acids, Arch. Intern. Med. 130: 478–487, 1972.
Nakagawa, S., Makino, I., Ishizaki, T. and Dohi, I.: Dissolution of cholesterol gallstones by ursodeoxycholic acid, Lancet 2: 367–369, 1977.
Ota, K., Kurita, S., Nishimura, M., Ogawa, M., Kamei, Y., Imai, K., Ariyoshi, Y., Kataoka, K., Murakami, M., Oyama, A., Hoshino, A. and Amo, H.: Combination therapy with Mitomycin C (NSC-26980), 5-Fluorouracil (NSC-19893), and Cytosine Arabinoside (NSC-63878) for advanced cancer in man, Cancer Chemother. Rep. 56: 373–385, 1972.
Sallan, S.E., Zinberg, N.E. and Frei, E. III.: Antiemetic effect of Delta-9-Tetrahydrocannabinol in patients receiving cancer chemotherapy, N. Engl. J. Med. 293: 795–797, 1975.
Tatsumura, T., Sato, H., Mori, A., Komori, Y. and Ainoda, Y.: Preventive effect of ursodeoxycholic acid on gastro-intestinal disorder caused by anticancer drugs, Jap. J. Cancer Clin., 24: 670–674, 1978. (in Japanese)
Wormsley, K.G.: Stimulation of pancreatic seretion by intraduodenal infusion of bile-salts, Lancet 19: 586–588, 1970.
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Formerly Satyadharma Lambana
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Tatsumura, T., Sato, H., Yamamoto, K. et al. Ursodeoxycholic acid prevents gastrointestinal disorders caused by anticancer drugs. The Japanese Journal of Surgery 11, 84–89 (1981). https://doi.org/10.1007/BF02468874
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DOI: https://doi.org/10.1007/BF02468874