Abstract
Based on the experimental results that operative stress of thoracotomy or laparothoracotomy has enhanced tumor growth remarkably in rats compared with laparotomy, a new combined treatment with by-pass operation, irradiation and immunochemotherapy was investigated in 39 advanced thoracic esophageal cancer patients. At by-pass operation, abdominal esophagus was divided and its proximal stump was closed immediately. Cervical esophagus was then divided and its distal stump was pulled out to the right supraclavicular region to make outer fistula. Thus, anticancer drug was poured into the esophagus through outer fistula very easily just before irradiation and then irradiation was performed under the condition that the lesion was immersed in the drugs. As anticancer agent, Mitomycin-C, 5-Fluorouracil or Bleomycin was given alternately. Lately, the combination of 5-Fluorouracil and Vitamin A was preferably used. The changes of immunological parameters and the survival after the onset of treatment was reported.
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References
Bagshaw, M. A.: Possible role of potentiators in radiation therapy,Amer J. Roentgenol. 85: 822–833 1961.
Hattori, T., Hamai, Y. and Ishii, T.: A new procedure for transabdominal resection of esophagocardial cancer and cervical anastomosis obviating thoracotomy,Jpn. J. Surg. 5: 211–221, 1975.
Hattori, T., Hamai, Y., Ikeda, H., Harada, T. and Ikeda, T.: Enhancing effect of thoracotomy on tumor growth in rats,Gann 69: 401–406, 1978.
Japanese Research Society for Gastric Cancer: The general rules for the gastric cancer study in surgery,Jpn. J. Surg. 3: 61–71, 1973.
Japanese Society for Esophageal Diseases: Guide lines for the clinical and pathologic studies on carcinoma of the esophagus,Jpn. J. Surg. 6: 69–78, 1976.
Komiyama, S., Hiroto, I., Kuwano, M., Endo, H. and Koga, K.: Enhancement of radiation effect on transformed fibroblastic cells by a synergistic combination of 5-fluorouracil and polyenes in vitro,Gann 65: 85–87, 1974.
Komiyama, S.: Combined treatment of 5-fluorouracil, vitamin A and radiation; FAR therapy,Gan to Kagaku-Ryoho, 4: Suppl., 91–95, 1977, (in Japanese).
Kuwano, M., Akiyama, S., Endo, H. and Koga, K.: Potentiation of fusidic acid and lentinan effects upon normal and transformed fibroblastic cells by amphotericin B,Biochem. Biophys. Res. Commun. 49: 1241–1248, 1972.
Toge, T., Ikeda, H., Senou, N., Niimoto, M. and Hattori, T.: Leucocyte responsiveness to Phytohemagglutinin (PHA) and serum inhibitory effect in patients with gastric cancer,Jpn. J. Surg. 7: 157–163, 1976.
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Supported in part by Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture.
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Hattori, T., Hamai, Y., Nagusa, Y. et al. Combined treatment with by-pass operation, irradiation and immunochemotherapy for advanced thoracic esophageal cancer. The Japanese Journal of Surgery 9, 118–124 (1979). https://doi.org/10.1007/BF02468846
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DOI: https://doi.org/10.1007/BF02468846