Abstract
Three types of autovein grafting procedures have been commonly employed for peripheral arterial reconstruction, that is, non-reversed, resersed and in-situ autovein grafting, and these procedures were comparatively studied in dogs to assess the best one for grafting. In the fibrinolytic activity of the internal surface of the grafts, as measured by standard fibrin plate method and Todd's fibrin slide technique, the in-situ autovein graft showed the highes activity, 139.5% in the mean, followed by 18% (mean) in the reversed autovein graft and 5.2% (mean) in the nonreversed autovein graft. The extent of fibrous proliferation of the pseudointima was least in the in-situ graft followed by the reversed and the non-reversed graft. These results suggest that preservation of the vasa vasorum is the most impotant factor to minimize fibrous proliferation of the graft pseudointima and to maintain high fibrinolytic activity on the internal surface of the graft. Consequently, the in-situ autovein grafting appears to be the most suitable method to ensure peripheral arterial continuity following surgical reconstruction.
Similar content being viewed by others
References
Astrup, T., Albrechtsen, O.K. and Claarssen, M. et al.: Thromboplastic and fibrinolytic activity of the human aorta. Cir. Res., 7: 969–976, 1959.
Downs, A.R.: Repair of late vein graft occlusion. Arch. Surg. 103: 689–643, 1971.
Fukumitsu, T.: Effect of temporary arterio-venous shunt and various antithrombotic agents on the venous reconstruction. Fukuoka Acta Medica, 65: 636–675, 1974. (English Abst.)
Inokuchi, K. and Kusaba, A.: Atherosclerosis in vascular surgery. Clinical Physiology. 2: 259–266, 1972. (in Japanese)
LoGerfo, F.W., Corson, J.D. and Mannick, J.A.: Improved result with femoropopliteal vein graft for limb salvage. Arch. Surg., 112: 567–570, 1977.
Pandolfi, M., Robertson, B. and Nilsson, I.M.: Fibrinolytic activity of human veins in arms and legs. Thrombos. Diathes. Haemorrh., 20: 247–256, 1968.
Pandolfi, M., Isacsson, S. and Nilsson, I.M.: Low fibrinolytic activity in the wall of veins in patients with thrombosis. Acta Med. Scand., 186: 1–5, 1969.
Ramsburgh, S.R., et al.: Femoro-popliteal bypass for limb salvage. Surgery, 81: 453–458, 1977.
Tanaka, K.: A histological examination of angiopathy in Buerger's desease. Report of Research Group of The Ministry of Welfare of Specified Disease “Buerger's Disease”. p. 38–40, 1975. (in Japanese)
Todd, A.S. and Nunn, A.: Fibrinolytic activity in tissue and thrombi. Union Chemica Medicamenta, Turin, p. 57–77, 1976.
Todd, A.S.: The histological localization of fibrinolysin activator. J. Path. Bact. 78: 281–283, 1959.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Furuyama, M., Kusaba, A., Moriyama, M. et al. Comparative study of the fibrinolytic activity of pseudointima in varying types of autovein grafting. The Japanese Journal of Surgery 10, 321–327 (1980). https://doi.org/10.1007/BF02468795
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02468795