Differential diagnosis of maldigestion and malabsorption of fat
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To determine whether or not purified131I-triolein produces the same behavior as14C-triolein in the intraluminal phase, and to assess whether or not 0.10±0.02 of the Digestion-Absorption Index (DAI) obtained from clinical cases is an adequate value for differentiating maldigestion from malabsorption of fat, dogs, pancreatic juice-deficient, short bowel and biledeficient were prepared. Both the pancreatic juice-deficient and bile-deficient groups indicated a high fecal excretion of14C-and131I-radioactivity, and the short bowel group indicated a moderate fecal excretion of fat. Daily fecal fat levels in each group were in parallel to the 3-day fecal excretion of radioactivity. However, the Digestion-Absorption Index of the pancreatic juice-deficient group was 0.602 in14C and 0.620 in131I, and indicated that a considerable portion of the ingested triolein was excreted into the feces without hydrolysis. DAI in the short bowel group were 0.020 in14C and 0.022 in131I, and in the bile-deficient group, the indices were 0.031 in14C and 0.021 in131I. Both latter groups showed a malabsorptive defect. Additionally, the Digestion-Absorption Index of the pancreatic juice-deficient group was higher than 0.10±0.02 of the clinical borderline mentioned in the foregoing paper, and that of the other two groups was lower. Therefore, this borderline may represent adequate values for the differentiation of fat malassmilation. On the other hand, it was confirmed that14C-triolein and131I-triolein showed similar behavior in the intraluminal phase, and that the131I-triolein test was adequate for clinical testing for fat digestion and absorption.
Key Wordsmaldigestion malabsorption fat 131I-triolein Digestion-Absorption index
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