Abstract
We have treated 40 patients with thymoma. All the 18 with benign thymoma were treated with resection alone and none had a tumor recurrence or died from disease-related causes. Postoperative survival in this group ranged from 2 months to 14 years. Of the 22 patients with malignant thymoma, 2 underwent total resection, 10 partial resection and 10 were non-resectable. Fifteen of the 20 patients with non-resectable and partially excised thymomas were given radiotherapy. The cumulative 5- and 10-year survival rate of irradiation treated patients was 45.6%, and 34.4%, respectively. Of 6 non-irradiated patients, only one who underwent complete excision of tumors survived for more than 10 years, and 5 died within 3 years after treatment. Based on our findings we suggest that all patients with malignant thymoma, irrespective of the extent of surgical treatment, should be given postoperative irradiation.
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Batat, M.A., Martini, N., Huvos, A.G., Aguilar, R.I. and Beattie, E.J. Jr.: Thymomas: Clinicopathologic features, therapy and prognosis,Cancer 34: 389–396, 1974.
Bergh, N.P., Gatzinsky, P., Larsson, S., Lundin, P. and Ridell, B.: Tumors of the thymus and thymic region: I. Clinicopathologic studies on thymomas,Ann. Thorac. Surg. 25: 91–98, 1978.
Cohn, L.H. and Grinnes, O.F.: Surgical management of thymic neoplasms,Surg. Gynecol. Obstetrics. 131: 206–215, 1970.
Jain, U. and Frable, W.J.: Thymoma. Analysis of benign and malignant,J. Thorac. Cardiovasc. Surg. 67: 310–321, 1974.
Wilkins, S.W. Jr., Edmunds, L.H. and Castleman, B.: Cases of thymoma at the Massachusetts General Hospital,J. Thorac. Cardiovasc. Surg. 52: 322–330, 1966.
Braitman, H., Li, W., Herrmann, C. Jr. and Mulder, D.G.: Surgery for thymic tumors,Arch. Surg. 103: 14–16, 1971.
Bernatz, P.E., Harrison, E.G. and Clagett, O.J.: Thymoma: Clinicopathologic study,J. Thorac. Cardiovasc. Surg. 42: 424–444, 1961.
Sawyers, J.L. and Foster, J.H.: Surgical treatment of thymomas,Arch. Surg. 96: 814–817, 1968.
Penn, C.R.H. and Hope-Stone, H.F.: The role of radiotherapy in the management of malignant thymoma,Brit. J. Surg. 59: 533–539, 1972.
Effler, D.B. and McCormack, L.J.: Thymic neoplasma,J. Thorac. Surg. 31: 607–677, 1959.
Boyd, D.P. and Berard, F.P.: A report upon the surgical significance of the thymus,New Eng. J. Med. 263: 431–436, 1960.
Legg, M.A. and Brady, W.J.: Pathology and clinical behavior of thymomas. A Survey of 51 cases,Cancer 18: 1311–1444, 1965.
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Hara, N., Yoshida, T., Furukawa, T. et al. Thymoma: Clinicopathologic features, therapy, and prognosis. The Japanese Journal of Surgery 10, 232–237 (1980). https://doi.org/10.1007/BF02468753
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DOI: https://doi.org/10.1007/BF02468753