Advertisement

Chromatographia

, Volume 49, Issue 9–10, pp 503–508 | Cite as

Recovery of a bioactive sesquiterpene lactone fromTanacetum parthenium by extraction with supercritical carbon dioxide

  • A. Kery
  • E. Ronyai
  • B. Simandi
  • E. Lemberkovics
  • T. Keve
  • A. Deak
  • S. Kemeny
Originals

Summary

The isolation of parthenolide-rich products from feverfew (Tanacetum parthenium (L.) Sch.) with supercritical carbon dioxide extraction has been investigated. A 32 full-factorial design was used to map the effects of pressure and temperature on the extraction yields and on the yield of parthenolide. The composition of the essential oil of feverfew obtained by hydrodistillation was compared with that of the SFE extract containing the volatile compounds.

Key Words

Supercritical-fluid extraction Feverfew Parthenolide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    W. A. Groenewegen, S. Heptinstall, J. Pharm. Pharmacol.42(8), 535 (1990).Google Scholar
  2. [2]
    D. Gromek, W. Kisiel, A. Stojakowska, S. Kohlmünzer, Pol. J. Pharmacol. Pharm.43(3), 213 (1991).Google Scholar
  3. [3]
    A. N. Makheja, J. M. Bailey, Lancet 2 (8254), 1054 (1981).CrossRefGoogle Scholar
  4. [4]
    W. A. Groenewegen, D. W. Knight, S. Heptinstall, Lancet 2, 1071 (1985).Google Scholar
  5. [5]
    W. A. Groenewegen, D. W. Knight, S. Heptinstall, J. Pharm. Pharmacol.38(9), 709 (1986).Google Scholar
  6. [6]
    S. Heptinstall, W. A. Groenewegen, P. Spangenberg, W. Loesche, J. Pharm. Pharmacol.39(6), 459 (1987).Google Scholar
  7. [7]
    L. A. J. O'Neill, M. L. Barrett, G. P. Lewis, Br. J. Clin. Pharmacol.23(1), 81 (1987).Google Scholar
  8. [8]
    T. R. Govindachari, B. S. Joshi, V. N. Kamat, Tetrahedron21(6), 1509 (1965).CrossRefGoogle Scholar
  9. [9]
    E. Bloszyk, B. Geppert, B. Drozdz, Planta Med34(1), 79 (1978).CrossRefGoogle Scholar
  10. [10]
    D. Fontanel, S. Bizot, P. Beaufils, Plant Med. Phytother.24(4), 231 (1990).Google Scholar
  11. [11]
    D. V. C. Awang, B. A. Dawson, D. G. Kindack, C. W. Crompton, S. Heptinstall, J. Nat. Prod.54(6), 1516 (1991).CrossRefGoogle Scholar
  12. [12]
    A. Kery, Gy. Turiak, P. Tetenyi, J. Chromatogr.446, 157 (1988).CrossRefGoogle Scholar
  13. [13]
    P. Mengal, B. Monpon, PCT Int. Appl. WO 94 06800, 1994, 19 pp.Google Scholar
  14. [14]
    N. Beuscher, I. Willigmann, Eur. Pat. Appl. EP 533658, 1993, 6 pp.Google Scholar
  15. [15]
    A. Rhodes, PCT Int. Appl. WO 92 11857, 1992, 18 pp.Google Scholar
  16. [16]
    E. Stahl, K.-W. Quirin, D. Gerard, Verdichtete Gase zur Extraktion und Raffination, Akademie Verlag, Berlin, 1987.Google Scholar
  17. [17]
    M. Perrut, 2ème Colloque sur les Fluides Supercritiques, INPL, Paris 1991, 11.Google Scholar
  18. [18]
    G. Brunner, Gas Extraction, An Introduction to the Fundamentals of Supercritical Fluids and the Application to Separation Processes, Steinkopff, Darmstadt, 1994.Google Scholar
  19. [19]
    E. Reverchon, J. Supercritical Fluids10, 1 (1997).CrossRefGoogle Scholar
  20. [20]
    R. M. Smith, M. D. Burford, J. Chromatogr. Sci.32, 265 (1994).Google Scholar
  21. [21]
    R. M. Smith, M. D. Burford, J. Chromatogr. Sci.627, 255 (1992).CrossRefGoogle Scholar
  22. [22]
    M. Oszagyan, B. Simandi, J. Sawinsky, A. Kery, E. Lemberkovics, J. Fekete, Falvour and Fragrance Journal11, 157 (1996).CrossRefGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1999

Authors and Affiliations

  • A. Kery
    • 1
  • E. Ronyai
    • 2
  • B. Simandi
    • 2
  • E. Lemberkovics
    • 1
  • T. Keve
    • 3
  • A. Deak
    • 2
  • S. Kemeny
    • 2
  1. 1.Institute of PharmacognosySemmelweis University of MedicineBudapestHungary
  2. 2.Department of Chemical EngineeringTechnical University of BudapestBudapestHungary
  3. 3.Gradiens Ltd.BudapestHungary

Personalised recommendations