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Evidences for temperature-dependent mechanism of host-guest complexation

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Summary

High-performance liquid chromatography and ultraviolet spectroscopy methods were applied to the studies on the influence of temperature on the complexation of β-cyclodextrin with naphthalene and its derivatives. The strong nonlinearity of Van't Hoff plots suggests, that the retention mechanism of hydrocarbons investigated might be different in high and low temperature region. The total lack of correlation (r=−0.230) between chromatographic data (capacity factors ratio:k PAH/k PAH×CD) and spectrophotometric data (ΔA) at high temperature (60°) as well as a significant correlation (r=0.922) at subambient temperature (15°C) suggest, that the inclusion mechanism starts to be important at low temperature region and the predominant mechanism for chromatographic retention is the formation of an inclusion complexes in the mobile phase.

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Authors and Affiliations

  1. Faculty of Pharmacy, Medical University of Gdańsk, Hallera 107, PL 80-416, Gdańsk, Poland

    P. K. Zarzycki & H. Lamparczyk

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  1. P. K. Zarzycki
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  2. H. Lamparczyk
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Zarzycki, P.K., Lamparczyk, H. Evidences for temperature-dependent mechanism of host-guest complexation. Chromatographia 48, 377–382 (1998). https://doi.org/10.1007/BF02467707

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