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A system for predicting the retentions of O-alkyl, n-(1-methylthioethylideneamino) phosphoramidates on RP-HPLC

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Summary

By using factor analysis, cluster analysis and multiple linear regression methods, two parameters, FHF and ECCR, were selected from eight solute-related structure parameters as showing the best correlation with retention data. The relationship between the retention data (k) and these two structure parameters were established for ten O-alkyl, O-(1-methylthioethylideneamino) phosphoramidate compounds under the experimental conditions studied. Retention data (k) for six other compounds that have a high correlation with structure parameters were predicted using these QSRR equations. The system was evaluated by comparing the experimentalk values with the predicted ones. Good agreement was obtained between the experimental and predictedk values.

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References

  1. S. A. Wise, L. C. Sander, R. Lapouyade, P. Garrigues, J. Chromatogr.541, 111 (1990).

    Article  Google Scholar 

  2. K. Jinno, M. Kuwajima, Chromatographic21, 541 (1986).

    Article  CAS  Google Scholar 

  3. T. Hamoir, B. Bourguignon, D. L. Massart, H. Hindriks, J. Chromatogr.633, 43 (1993).

    Article  CAS  Google Scholar 

  4. M. Bogusz, R. Aderjan, J. Chromatogr.435, 43 (1988).

    Article  CAS  Google Scholar 

  5. P. Lehtonen, Chromatographic19, 316 (1984).

    CAS  Google Scholar 

  6. P. Harmala, H. Vuorela, P. Lehtonen, R. Hiltunen, J. Chromatogr.507, 367 (1990).

    Article  CAS  Google Scholar 

  7. K. Jinno, K. Kawasaki, Chromatographic18, 90 (1984).

    Article  CAS  Google Scholar 

  8. Q. S. Wang, R. Y. Gao, H. Z. Yang, B. W. Yan, Chin. J. Chem. 9, 435 (1991).

    Article  CAS  Google Scholar 

  9. R. Kaliszan, A. Kaliszan, T. A. G. Noctor, W. P. Purcell, I. W. Wainer, J. Chromatogr.609, 69 (1992).

    Article  CAS  Google Scholar 

  10. M. H. Abraham, H. S. Chadha, A. J. Leo, J. Chromatogr. A685, 203 (1994).

    Article  CAS  Google Scholar 

  11. R. Kaliszan, Anal. Chem.64, 619A (1992).

    CAS  Google Scholar 

  12. M. A. Ridriguez Delgado, M. J. Sanchez, V. Gonzalez, F. Farcia Montelongo, J. Chromatogr. A697, 71 (1995).

    Article  Google Scholar 

  13. E. Forgacs, T. Cserhati, J. Chromatogr. A668, 395 (1994).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. National Laboratory of Elemento-Organic Chemistry, Nankai University, 300071, Tianjin, P. R. China

    Q. S. Wang, L. Zhang, M. Zhang, X. D. Xing & G. Z. Tang

Authors
  1. Q. S. Wang
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  2. L. Zhang
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  3. M. Zhang
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  4. X. D. Xing
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  5. G. Z. Tang
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Wang, Q.S., Zhang, L., Zhang, M. et al. A system for predicting the retentions of O-alkyl, n-(1-methylthioethylideneamino) phosphoramidates on RP-HPLC. Chromatographia 49, 444–448 (1999). https://doi.org/10.1007/BF02467621

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  • DOI: https://doi.org/10.1007/BF02467621

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