Summary
A capillary gas chromatographic method is described for the determination of cisplatin based on the complexation of platinum(II) with bis(isovalerylacetone) ethylenediimine (H2IVA2en) and extraction in chloroform. The chromatography was carried out on a BP1 or a BP5 column with an FID. Copper(II), nickel (II) and palladium(II) separated completely and did not affect the determination of platinum(II). The method was applied of the determination of cisplatin in a pharmaceutical preparation and blood samples of cancer patients after infusion of cisplatin. The amounts of cisplatin in blood were found to be within 246–283 ng mL−1 with a C.V. of 2.35–4.26%.
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References
A. Bonetti, T. Franceschi, P. Apastoli, A. Messori, L. Sperotto, G. L. Cetto, A. Molino, R. Leone, Ther. Drug Monit.17, 25 (1995).
C. Boshoff, R. T. D. Oliver, C. J. Gallagher, J. Ong. Eur. J. Cancer Part A,31A, 1633 (1995).
Y. Chen, J. Guo, Guangpoxue Yu Guangpu Fenxi11, 11 (1991).
A. EI-Yazigi, I. Al-Saleh, Ther. Drug. Monit.8, 318 (1986).
S. M. Hopfer, L. Ziebka, F. W. Jun. Sunderman, J. R. Sporn, B. R. Greenberg, Ann. Clin. Lab. Sci.19, 389 (1989).
F. B. Lo, D. K. Arai, M. A. Nazar, J. Anal. Toxicol.11, 242 (1987).
W. R. L. Cairns, L. Ebdon, S. J. Hill, Anal. Proc.31, 295 (1994).
Y. Q. Li, W. X. Mo, Y. G. Zhang, Y. Liang, Lihua Jianyan Huaxue Fence29, 329 (1993).
V. Brabee, O. Virana, V. Kleinwaechter, collect. Czech. Chem. Common.48, 2903 (1983).
K. C. Marsh, L. A. Sternson, A. J. Repta, Anal. Chem.56, 491 (1984).
H. H. Farrish, P. H. Hsyu, J. F. Pritchard, K. R. Brouwer, J. Jarrett, J. Pharm. Biomed. Anal.12, 265 (1994).
A. Anderson, H. Ehrsson, J. Chromatogr. B,652, 203 (1994).
H. Wetzstin, H. P. Schroeer, Pharmazie39 124 (1984).
F. Elferink, W. J. F. Vander Vijgh, H. M. Pinedo, Anal. Chem.58, 2293 (1986).
P. J. Parsons, P. F. Morrison, A. F. Le Roy, J. Chromatogr.385, 323 (1987).
L. A. Sterson, K. C. Marsh, S. J. Bannister, A. J. Repta, Anal. Proc. (London)20, 366 (1983)
X. D. Ding, L. S. Krull, J. Liq. Chromatogr.6, 2173 (1983).
W. N. Richmond, R. P. Baldwin, Anal. Chim. Acta154, 133 (1983).
R. A. Baumann, C. Gooijer, N. H. Vetthorst, R. W. Frei, I. Klein, W. J. F. Vander Vijgh, J. Pharm. Biomed. Anal.5, 165 (1987).
M. Y. Khuhawar, S. N. Lanjwani, S. A. Memon, J. Chromatogr B,693, 175 (1997).
R. Belcher, K. Blessel, T. Cardwel, M. Pravica, W. I. Stephen, P. C. Uden, J. Inorg. Nucl. Chem.35, 1127 (1973).
R. Belcher, R. J. Martin, W. I. Stephen, D. E. Henderson, A. Kamalizad, P. C. Uden, Anal. Chem.45, 1197 (1973).
Y. Zeng, L. A. Seeley, T. M. Dowling, P. C. Uden, M. Y. Khuhawar, J. High Res. Chromatogr.15, 669 (1992).
L. F. Lindoy, M. E. Moody, D. Tayer, Inorg. Chem.16, 1962 (1977).
M. Y. Khuhawar, A. G. M. Vasandani, A. I. Soomro, J. Chem. Soc. Pak.12, 119 (1990).
M. Y. Khuhawar, A. I. Soomro, J. Liq Chromatogr.15, 467 (1992).
M. Y. Khuhawar, A. Sarfraz Yazdi, P. C. Uden, J. Chromatogr.636, 271 (1993).
M. Y. Khuhawar, S. N. Lanjwani, Microchem. Acta129, 65 (1998).
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Khuhawar, M.Y., Memon, A.A. & Bhanger, M.I. The GC determination of cisplatin as platinum(II) from pharmaceutical preparations and blood sample of cancer patients. Chromatographia 49, 249–252 (1999). https://doi.org/10.1007/BF02467551
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DOI: https://doi.org/10.1007/BF02467551