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A methodological and metabolite identification study of the metabolism of S-carboxymethyl-L-cysteine in man

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Summary

The analysis of 08:00–16:00 (0–8) hour urine collections following oral S-carboxymethyl-L-cysteine administration of 750 mg to 30 individuals identified S-carboxymethyl-L-cysteine, S-carboxymethyl-L-cysteine S-oxide, S-methyl-L-cysteine and S-methyl-L-cysteine S-oxide as the major urinary drug related compounds. No S-(carboxymethylthio)-L-cysteine mixed disulphide metabolite was found in the 08:00–16:00 hour urine collection but the metabolite was detected in the 16:00–00:00 (8–16) hour urune collection by paper chromatography, TLC and HPLC. The production of the S-oxide metabolites 08:00–16:00 hour urine collection) and the mixed disulphide metabolite (16:00–00:00 hour urine collection) were both shown to be biomodally distributed. A significant linear correlation of the S-oxides recovered following 08:00–16:00 hour urine collection as analysed by paper chromatography, TLC and HPLC is reported.

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  1. Department of Pharmacy, King's College London, Manresa Road, SW3 6LX, London, UK

    G. B. Steventon

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Steventon, G.B. A methodological and metabolite identification study of the metabolism of S-carboxymethyl-L-cysteine in man. Chromatographia 48, 561–568 (1998). https://doi.org/10.1007/BF02466650

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  • DOI: https://doi.org/10.1007/BF02466650

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