Patients with multiple sclerosis were found to have increased cerebrospinal fluid, noradrenaline, and excitatory amino acid (glutamate and aspartate) levels, with increased blood glutamine, asparagine, and glycine levels. An association was found between these biochemical parameters and the nature and severity of neurological symptoms, as well as with the course of the disease. Neurotransmitters are proposed to have a role in the pathogenesis of multiple sclerosis, particularly in the biochemical mechanisms of the relationship between the nervous and immune systems, as well as in the neurochemical mechanisms underlying the development of neurological deficit.
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É. G. Larskii, V. P. Barkhatova, and E. G. Demin. Lab. Delo,9, 519–522 (1985).
D. L. Bellinger, D. Lorton, and S. Y. Felten, Int. J. Immunopharmacol.,14, No. 3, 329–344 (1992).
E. Chelmicka-Schorr and B. G. Arnason, Ann. Neurol.,36, Suppl., 29–32 (1994).
A. Compston, Ann. Neurol.,36, Suppl., 146–150 (1994).
R. A. Davidoff, in: The Origin and Treatment of Spasticity, R. Benecke, M. Emre, and R. Davidoff (eds.), USA (1990), pp. 63–91.
C. D. Dijkstra, E. R. van der Voort, C. J. de Groot, et al., Psychoneuroendocrinology,19, No. 2, 135–142 (1994).
V. Gallai, P. Sarchielli, C. Firenze, et al., Acta Neurologica Belgica,94, No. 1, 44–52 (1994).
J. Jackson, R. Cross, and R. Walker, Immunology,54, 505–512 (1985).
J. W. Karaszewski, A. T. Reder, D. Anlar, et al., Ann. Neurol.,30, 42–47 (1991).
J. W. Karaszewski, A. T. Reder, D. Anlar, and G. W. Arnason, J. Neuroimmunol.,43, No. 1-2, 1–7 (1993).
F. Lechin, D. van der Dijs, A. Lechin, et al., J. Med.,25, No. 3-4, 181–192 (1994).
S. Lipton and R. Rosenberg, New England J. Med.,330, 613–622 (1994).
W. H. Oertel, in: Spasticity: The Current Status of Research and Treatment, M. Emre and R. Benecke (eds.), USA (1989), pp. 27–44.
J. W. Prineas and F. Connell, Curr. Neurol.,28, 68–75 (1979).
J. S. Wolinsky, Curr. Neurol.,13, 167–207 (1993).
Institute of Neurology, Russian Academy of Medical Sciences, Moscow. Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 97, No. 5, pp. 7–10, May, 1997.
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Barkhatova, V.P., Zavalishin, I.A., Askarova, L.S. et al. Changes in neurotransmitters in multiple sclerosis. Neurosci Behav Physiol 28, 341–344 (1998). https://doi.org/10.1007/BF02464784
- Multiple Sclerosis
- Multiple Sclerosis Patient
- Excitatory Amino Acid
- Acute Disseminate Encephalomyelitis