Mycoscience

, Volume 41, Issue 4, pp 293–295 | Cite as

Effects of Maitake (Grifola frondosa) glucan in HIV-infected patients

  • Hiroaki Nanba
  • Noriko Kodama
  • Douglas Schar
  • Denise Turner
Original Papers

Abstract

The effects of MD-Fraction, a β-glucan extracted from Maitake mushroom (Grifola frondosa), on the health status of individuals suffering from HIV infection were evaluated in a long-term trial. The HIV status of the 35 respondents who participated in the study was followed by monitoring CD4+ cell counts, viral load measure, symptoms of HIV infection, status of secondary disease, and sense of well-being. Twenty patients reported an increase in CD4+ cell counts to 1.4–1.8 times, and 8 patients reported a decrease to 0.8–0.5 times. Viral load was reported to increase in 9 patients and decrease in 10 patients. However, 85% of respondents reported an increased sense of well-being with regard to various symptoms and secondary diseases caused by HIV. These results suggest that Maitake D-Fraction had a positive impact in HIV patients.

Key Words

anti-HIV activity CD4+ cell Grifola frondosa (Maitake) IL-2 MD-Fraction 

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Literature cited

  1. Hishida I., Nanba H. and Kuroda H. 1988. Anti-tumor activity exhibited by oral administered extract from fruit body ofGrifola frondosa (Maitake). Chem. Pharm. Bull.36: 1819–1827.PubMedCrossRefGoogle Scholar
  2. Nanba H., Hamaguchi A. and Kuroda H. 1987. The chemical structure of an anti-tumor polysaccharide in fruit bodies ofGrifola frondosa (Maitake). Chem. Pharm. Bull.35: 1162–1168.PubMedCrossRefGoogle Scholar
  3. Nanba H. and George S. R. 1993. Effects of Maitake (Grifola frondosa) for HIV-positive or fibroid tumor patients. 113th Congr. Pharmaceutical Society of Japan, Osaka, Japan, March 29–31, p. 212.Google Scholar
  4. Nanba H. 1993. Anti-tumor activity of orally administered D-Fraction from Maitake mushroomGrifola frondosa. J. Naturopath. Med.4: 10–15.Google Scholar

Copyright information

© The Mycological Society of Japan 2000

Authors and Affiliations

  • Hiroaki Nanba
    • 1
  • Noriko Kodama
    • 1
  • Douglas Schar
    • 2
  • Denise Turner
    • 2
  1. 1.Department of Microbial ChemistryKobe Pharmaceutical UniversityKobeJapan
  2. 2.Herbal Clinical ResearchLondonUK

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