Role of calcineurin in regulation of high voltage-activated calcium channel activity
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In the Review, personal data of the Author and the data of other experimenters on calcium/calmodulin-dependent protein phosphatase-2B (calcineurin) are summarized and analyzed; the role of this enzyme in regulation of the calcium channel activity in the membrane of excitable cells is discussed. A two-phase mechanism of Ca-dependent suppression of the activity of Ca channels in the molluscan neurons is described in details. Special attention is paid to the analysis of changes in the activity of Ca channels in the transfected hybrid cells overexpressing calcineurin.
KeywordsProtein Phosphatase Dorsal Root Ganglion Neuron Okadaic Acid PP2B Activity Protein Phosphatase Inhibitor Okadaic Acid
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