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Content of endogenous opiates and adrenocorticotropic hormone in the brain structures of rats of different ages

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Abstract

The contents of beta-endorphin (BE), methionine-enkephalin (MEK), and adrenocorticotropic hormone (ACTH) in the hypophysis and hypothalamus of intact 4- to 6-week-old and 16-week-old Wistar rats was studied. The maximum BE concentration was found in the hypophysis, whereas the maximum MEK and ACTH concentrations were found in the hypothalamus. Aging was followed by a decrease in the concentrations of all above substances, except BE, whose concentration in the hypophysis of the older rat group was markedly higher than in the hypophysis of 4- to 6-week-old animals.

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References

  1. Yu. B. Lishmanov, Yu. A. Travkov, T. V. Fedotova, et al., “Effects of opiate neuropeptides on the system of prostaglandins and the processes of lipid peroxidation in the myocardium during its stress damage,”Byull. Éksp. Biol. Med.,111, No. 6, 619–621 (1991).

    CAS  Google Scholar 

  2. V. G. Smagin, V. T. Vinogradov, and S. A. Bulgakov,Ligands of Opiate Receptors: Gastro-Enterological Aspects [in Russian], Nauka, Moscow (1983).

    Google Scholar 

  3. E. del Pozo, J. Martin-Perez, and A. Stadelman, “Inhibitory action of met-enkephalin on ACTH release in man,”J. Clin. Invest.,65, No. 6, 1531–1534 (1980).

    Article  PubMed  Google Scholar 

  4. G. Tsetler “Active peptides in nervous tissue,” in:Endorphins [Russian translation], E. Costa and M. Trabukki (eds.), Mir, Moscow (1981), pp. 15–34.

    Google Scholar 

  5. I. V. Shishkina, V. I. Babichev, and Yu. A. Pankov, “Effects of endogenous opiates on formation of the reproductive function in rats,”Byull. Éksp. Biol. Med.,112, No. 9, 232–234 (1991).

    CAS  Google Scholar 

  6. R. Franceschini, “Calcitonin and beta-endorphin secretion,”Biomed. Pharmacother.,417, No. 8, 305–309 (1993).

    Article  Google Scholar 

  7. E. F. Blyum, J. Rossye, E. L. F. Battenberg, et al., “Beta-endorphin. Localization in the cell, electrophysiological and behavioral aspects,” in:Endorphins [Russian translation], E. Costa and M. Trabukki (eds.), Mir, Moscow (1981), pp. 97–117.

    Google Scholar 

  8. O. A. Gomazakov and O. O. Grigoryants, “Regulation of enkephalin biosynthesis: biochemical and physiological aspects,”Usp. Sovrem. Biol.,108, No. 1, 109–123 (1989).

    Google Scholar 

  9. Yu. B. Lishmanov, M. V. Trifonova, A. N. Tsybin, et al., “Beta-endorphin and stress hormones of blood plasma during strain and adaptation states,”Byull. Éksp. Biol. Med.,103, No. 4, 422–424 (1987).

    CAS  Google Scholar 

  10. V. N. Slavnov, G. V. Valuyeva, E. V. Luchitskii, et al., “Effects of beta-endorphin on some endocrine functions,”Byull. Éksp. Biol. Med.,96, No. 12, 5–7 (1983).

    CAS  Google Scholar 

  11. R. Gaiger, “Chemistry of regulation by neuropeptides” in:Endorphins [Russian translation], E. Costa and M. Trabukki (eds.), Mir, Moscow (1981), pp. 35–42.

    Google Scholar 

  12. R. N. Glebov and T. V. Goryacheva, “ACTH as a neuropeptide. Physiological role of ACTH in the brain,”Patol. Fiziol. Éksp. Ther.,4, 54–57 (1990).

    Google Scholar 

  13. A. Santagostino, D. Cochchi, G. Gianyoni, et al., “Some interrelations between endorphins and hormones of the hypophysis,” in:Endorphins [Russian translation], E. Costa and M. Trabukki (eds.), Mir, Moscow (1981), pp. 178–184.

    Google Scholar 

  14. V. M. Borzenkov, A. P. Pomerantsev, and I. P. Ashmarin, “Additive synthesis of regulatory peptidein vivo: administration of vaccine strainFrancisella Tularensis producing beta-endorphin,”Byull. Éksp. Biol. Med.,116, No. 8, 151–153 (1993).

    CAS  Google Scholar 

  15. S. Gigauri, V. V. Dolgov, and T. N. Pavlova,Ethical Requirements to the Work with Experimental Animals. A Textbook [in Russian], TSOLIUV, Moscow (1988).

    Google Scholar 

  16. O. H. Lowry, N. J. Rosenbrough, A. L. Farr, et al., “Protein with the folin phenol reagent,”J. Biol. Chem. 193, 265 (1951).

    PubMed  CAS  Google Scholar 

  17. M. D. Mashkovskii, “Enkephalins and endorphins are a new class of biogenic physiologically active substances,”Terapevt. Arkh.,50, No. 5, 126–135 (1978).

    CAS  Google Scholar 

  18. I. P. Zapadnyuk, V. I. Zapadnyuk, E. A. Zakharia, et al.,Laboratory Animals: Breeding, Keeping, Use in Experiments [in Russian], Vyshcha Shkola, Kiev (1983).

    Google Scholar 

  19. V. G. Shalyapina and N. A. Chemyrtan, “About the functional role of adrenocorticotropine in postnatal ontogenesis of rats,”Probl. Éndokrinologii,30, No. 5, 71–74 (1984).

    CAS  Google Scholar 

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  1. Lugansk State Medical University, Ministry of Public Health of Ukraine, Ukraine

    A. N. Voloshin & I. A. Komarevtseva

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  1. A. N. Voloshin
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  2. I. A. Komarevtseva
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Voloshin, A.N., Komarevtseva, I.A. Content of endogenous opiates and adrenocorticotropic hormone in the brain structures of rats of different ages. Neurophysiology 29, 127–129 (1997). https://doi.org/10.1007/BF02463285

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