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Bulletin of Mathematical Biology

, Volume 44, Issue 2, pp 215–229 | Cite as

Electromagnetic mediated pharmacokinetics in a three-layer diffusional system

  • Y. J. Seto
  • S. T. Hsieh
Article
  • 22 Downloads

Abstract

The effect of an applied electromagnetic field on drug diffusion in a one dimensional, three-layer drug-receptor model has been analyzed and expressed in terms of a normalized turnover rate parameter. The analysis reveals that an imposed harmonic time-varying electromagnetic field may enhance or retard the drug turnover rate depending on the diffusional pattern, the equivalent Michaelis constant, the maximum drug turnover rate of the intrinsic drug-receptor system, as well as the power density and frequency of the applied electromagnetic field. It is estimated that the power density in the order of magnitude of 1μW/cm2 at 100 MHz frequency range may be required to induce significant rate effects.

Keywords

Drug Molecule Diffusion Pattern Intrinsic Diffusion Intrinsic System Turnover Rate Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Society of Mathematical Biology 1982

Authors and Affiliations

  • Y. J. Seto
    • 1
  • S. T. Hsieh
    • 1
  1. 1.Electroscience and Biophysics Research Laboratories, School of EngineeringTulane UniversityNew OrleansUSA

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