Improvements in the selective perception and training of rats using an original analog of the C-terminal fragment of vasopressin
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This report presents studies on the effects of intranasal administration of five doses (0.001, 0.01, 0.1, 1, and 10 μg/kg) of a new analog of arginine-vasopressin fragment AVP(6–9), i.e., D-MPRG, on the learning ability of rats with positive and negative reinforcement. All doses of the peptide improved learning. The most effective dose was 0.01 μg/kg, at which the peptide accelerated the acquisition of a conditioned active avoidance reflex both when given 1 h before and when given immediately after training sessions. The peptide had greater effects when animals were trained with negative reinforcement. Analysis of the results suggests that the action of D-MPRG is mainly on perception processes, i.e., extraction of the conditioned stimulus from the environmental surroundings and evaluation and enhancement of its biological significance. In addition, this peptide prevented extinction of the acquired habit and improved the processes of consolidation, though this effect was weaker than its effect on perception.
Key WordsMemory learning vasopressin fragment analog
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- 1.USSR Patent No. 1623166, 22 September 1990.Google Scholar
- 2.S. A. Titov, “The neurochemical bases of memory,” in:Neurochemistry [in Russian], I. P. Ashmarin and P. I. Stukalov (Eds.), Institute of Biomedical Chemistry Press, Russian Academy of Medical Sciences, Moscow (1996), pp. 372–414.Google Scholar
- 3.V. P. Golubovich, P. V. Martinovich, A. B. Usenko, L. K. Slobodchikova, S. A. Titov, and I. P. Ashmarin, “Synthesis and biological activity of C-terminal fragments of vasopressin,”Khim. Farm. Zh.,6, 675–679 (1988).Google Scholar
- 6.D. de Wied and W. H. Gispen, “Behavioral effects of peptides,” in:Peptides in Neurobiology, H. Jainer (Ed.), Bethesda (1977), pp. 397–425.Google Scholar
- 7.D. de Wied, “Vasopressin and memory processes,” in:Abstracts of 31st Int. Congress Physiol. Sci. Helsinki, 9–14 July 1989, p. 249.Google Scholar
- 9.J. J. Legros and M. Timsit-Berthier, “Vasopressin and vasopressin analogues for treatment of memory disorders in clinical practice,”Prog. Neuro-Psychopharmacol. Biol. Psychiatry,12, 571–586 (1988).Google Scholar