Advertisement

Neuroscience and Behavioral Physiology

, Volume 28, Issue 5, pp 513–520 | Cite as

Spontaneous activity of individual neurons in the human ventrolateral thalamus during changes in the functional state of the brain

  • S. N. Raeva
  • N. A. Vainberg
  • V. A. Dubynin
Article

Abstract

Background spike activity of 235 cells of the integrative subcortical motor center, i.e., the ventrolateral nucleus of the thalamus, were analyzed in nonanesthetized human brains during stereotaxic surgery in patients with various forms of Parkinson’s disease. Previous data on the existence of two major types of neurons with convergent properties in the ventrolateral nucleus were confirmed. These cell types are: 1) cells with irregular occasional activity, with a tendency for spikes to group into the frequency ranges 5±1 and 10–30 Hz (type A cells, 74%), and 2) cells with constant rhythmic (3–6 Hz) generation of short volleys of discharges, with an interval structure similar to that of low-threshold Ca2+-dependent volley activity (type B, 26%). This is the first report demonstrating that changes in the functional state of the brain (after repeated movement trials, in transient anesthesia) are accompanied by transiently occurring transformations of the initial irregular activity of A cells into a rhythmic, volley-like pattern whose interval structure was in some cases similar to the spike activity of B cells. Differences in the localizations of A and B neurons in the ventrolateral nucleus are described, along with differences in the correlation characteristics of their background spike activity with the pathological features of Parkinson’s disease (tremor, rigidity). The nature of the two types of convergent neurons in the ventrolateral nucleus is discussed, and a basis is laid for the importance of the functional factor in understanding the transformation of, their background spike activity, due to the properties of cell membranes and intercellular and interstructure interactions in conditions of the living nonanesthetized human brain.

Key words

Human thalamus ventrolateral nucleus microelectrodes activity of individual neurons Parkinson’s disease 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    S. N. Raeva, Microelectrode Studies of Human Cerebral Neuron Activity [in Russian], Moscow (1977).Google Scholar
  2. 2.
    S. N. Raeva and A. O. Lukashev, “Characteristics of the background neuron activity of the reticular nucleus of the human thalamus,” Neirofiziologiya,19, No. 4, 456–466 (1987).Google Scholar
  3. 3.
    S. N. Raeva, A. O. Lukashev, A. P. Lashin, N. Ya. Vasin, A. L. Kadin, V. A. Shabalov, and N. P. Grokhovskii, “Responses of neurons in the reticular nucleus of the human thalamus to verbal and sensory influences of different signal importance,” Neirofiziologiya,22, No. 4, 441–451 (1990).Google Scholar
  4. 4.
    D. Albe-Fessard, G. Guiot, Y. Lamarre, and G. Arfel, “Activation of thalamocortical projections related to tremorogenic processes,” in: The Thalamus, D. P. Purpura and M. D. Yahr (eds.), New York-London (1966).Google Scholar
  5. 5.
    R. Brown and C. Marsden, “Internal versus external cues and the control of affection in Parkinson’s disease,” Brain,111, 323–345 (1988).PubMedGoogle Scholar
  6. 6.
    L. Domich, G. Oakson, and M. Steriade, “Thalamic burst patterns in the naturally sleeping cat: a comparison between cortically projecting and reticular neurons,” J. Phsyiol. (London),379, 429–449 (1986).Google Scholar
  7. 7.
    E. V. Evarts, Y. Shinoda, and S. P. Wise, Neurophysiological Approaches to Higher Brain Functions, New York (1984).Google Scholar
  8. 8.
    I. A. Ilinsky, K. Kultas-Ilinsky, A. Rosina, and M. Haddy, “Quantitative evaluation of crossed and uncrossed projections from basal ganglia and cerebellum to the cat thalamus,” Neurosci.,21, 207–227 (1987).CrossRefGoogle Scholar
  9. 9.
    H. Jahnsen and R. Llinas, “Ionic basis for electroresponsiveness and oscillatory properties of guinea-pig thalamic neuronsin vitro,” J. Physiol. (London),349, 227–247 (1984).Google Scholar
  10. 10.
    H. H. Jasper and G. Bertrand, “Thalamic units involved in somatic sensation and voluntary and involuntary movements in man.,” in: The Thalamus, D. P. Purpura and M. D. Yahr (eds.), New York-London (1966).Google Scholar
  11. 11.
    E. G. Jones, The Thalamus, New York (1985).Google Scholar
  12. 12.
    F. A. Lenz, H. C. Kwan, J. O. Dostrovsky, R. R., Tasker, J. T. Murphy, and Y. E. Lenz, “Single-unit analysis of the human ventral thalamic nuclear group Activity correlated with movement,” Brain,113, 1795–1821 (1990).PubMedGoogle Scholar
  13. 13.
    F. A. Lenz, J. L. Vitek, and M. R. DeLong, “Role of the thalamus in parkinsonian tremor. Evidence from studies in patients and primate models,” Stereotact. Funct. Neurosurg.,60, 94–103 (1993).PubMedGoogle Scholar
  14. 14.
    C. Ohye, Y. Saito, A. Fukamashi, and H. Narabayashi, “An analysis of the spontaneous rhythmic and nonrhythmic burst discharges in the human thalamus,” J. Neurol. Sci.,22, 245–259 (1974).PubMedCrossRefGoogle Scholar
  15. 15.
    C. Percheron, C. Francois, and J. Yelnik, “Relations entre les ganglions de la base et le thalamus de primate. Nouvelles donnés morphologiques. Nouvelles interpretations physiopathologiques” Rev. Neurol.,142, 337–353 (1986).PubMedGoogle Scholar
  16. 16.
    S. N. Raeva, “Unit activity of the human thalamus during voluntary movements,” Stereotact. Funct. Neurosurg.,54–55, 154–158 (1990).PubMedGoogle Scholar
  17. 17.
    S. N. Raeva, “Unit activity of nucleus ventralis lateralis of human thalamus during voluntary movement,” Stereotact. Funct. Neurosurg.,60, 86–93 (1993).PubMedGoogle Scholar
  18. 18.
    M. Riclan and E. Levita, Subcortical Correlates of Human Behavior: A Psychological Study of Thalamus and Basal Ganglia Surgery, Baltimore (1969).Google Scholar
  19. 19.
    D. Scherman, C. Desnos, F. Darchen, P. Pollak, F. Javoy-Agid, and Y. Agid, “Striatal dopamine deficiency in Parkinson’s disease: role of aging,” Ann. Neurol.,26, 551–557 (1989).PubMedCrossRefGoogle Scholar
  20. 20.
    M. Steriade, E. G. Jones, and R. R. Llinas, Thalamic Oscillations and Signaling. J. Wiley and Sons, New York (1990).Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • S. N. Raeva
  • N. A. Vainberg
  • V. A. Dubynin

There are no affiliations available

Personalised recommendations