Abstract
Experiments on rats in which hydrocortisone was given in the early postnatal period were used to study the effects of intrastriatal microinjection of corticoliberin on behavior in an open field test. Bilateral microinjection of corticoliberin into the neostriatum led to a sharp reduction in orientational-investigative activity. Rats given hydrocortisone in the first five days of life had elevated movement activity, and the anxiogenic effect of corticoliberin was absent in these animals.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ya. Buresh, O. Bureshova, and D. P. Kh'youston, Principles and Practice of Experiments on the Brain and Behavior [in Russian], Vysshaya Shkola, Moscow (1991).
N. L. Voilokova, N. F. Suvorov, V. V. Rakitskaya, et al., “Conditioned reflex behavior in dogs given intracaudate corticoliberin,” Zh. Vyssh. Nerv. Deyat.,44, No. 3, 585 (1994).
K. N. Maslova and E. V. Naumenko, “Long-term modification of the hypothalamo-adrenocortical system by treatments in early postnatal ontogenesis,” in: Ontogenetic and Genetic-Evolutionary Aspects of the Neuroendocrine Regulation of Stress [in Russian], Nauka, Novosibirsk (1990), p. 40.
E. V. Naumenko, N. N. Dygalo, and L. N. Maslova, “Long-term modification of stress reactivity by treatments in prenatal ontogenesis,” in: Ontogenetic and Genetic-Evolutionary Aspects of the Neuroendocrine Regulation of Stress [in Russian], Nauka, Novosibirsk (1990), p. 55.
V. V. Rakitskaya, N. L. Voilokova, I. A. Garina, et al., “Neuroendocrine functions and behavior in dogs after administration of corticoliberin into the caudate nucleus,” Fiziol. Zh.,78, No. 1, 29 (1992).
G. Sel'e, Essays on Adaptational Syndrome [in Russian], Meditsina, Moscow (1960).
V. G. Shalyapina, V. V. Rakitskaya, I. A. Garina, et al., “Administration of corticoliberin into the caudate nucleus activates the sympathoadrenomedullary and hypophyso-adrenocortical systems by different mechanisms,” Fiziol. Zh. im. I. M. Sechenova,29, No. 1, 92 (1993).
E. De Souza, “Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution,” J. Neurosci.,7, 88 (1987).
J. Dorner, Hormones and Brain Differentiation, Amsterdam (1976).
A. Dunn and C. Berridge, “Physiological and behavioural responses to corticotropin releasing factor administration: is CRF a mediator of anxiety or stress responses?” Brain Res. Rev.,15, 71 (1990).
T. S. Gray, “Amygdaloid CRF pathways, role in autonomic neuroendocrine and behavioural responses to stress,” Ann. N. Y. Acad. Sci.,697, 53 (1993).
C. S. Hall, “Emotional behaviour in the rat. III. The relationship between emotionality and ambulatory activity,” J. Comp. Physiol.,22, 345 (1936).
S. Levine, “The psychoendocrinology of stress,” Ann. N. Y. Acad. Sci.,697, 61 (1993).
F. Manzaghi, S. Heinrichs, E. M. Pich, et al., “The role of limbic and hypothalamic corticotropin releasing factor in behavioural responses to stress,” Ann. N. Y. Acad. Sci.,697, 142 (1993).
J. Merchenthaler, S. Vigh, P. Petrusz, and A. V. Schally, “Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat brain,” Am. J. Anat.,165, 385 (1982).
B. W. O'Malley, “A review of the cellular biology of steroid hormones action in the chick oviduct,” in: The Role of Receptors in Biology and Medicine, Raven Press, New York (1986), p. 41.
M. J. Owens and C. B. Nemeroff, “Physiology and pharmacology of corticotropin releasing factor,” Pharmacol. Rev.,43, 425 (1991).
M. Sakanaka, T. Shibasaki and K. Lederis, “Corticotropin releasing factor-like immunoreactivity in the rat brain as revealed by a modified cobalt-glucose oxidase-diaminobenzidine method,” J. Comp. Neurol.,260, 256 (1987).
P. G. Smelic, “Adaptation and brain function,” in: Progress in Brain Research, E. K. de Kloe, et al. (eds.), Vol. 72, Elsevier, Amsterdam (1987), p. 3.
Additional information
I. P. Pavlov Institute of Physiology, St. Petersburg. Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 47. No. 1, pp. 130–135. January–February, 1997.
Rights and permissions
About this article
Cite this article
Shalyapina, V.G., Turkina, E.V., Rybnikova, E.A. et al. Modification of the behavioral effects of corticoliberin by early post-natal administration of corticosteroid hormones. Neurosci Behav Physiol 28, 299–303 (1998). https://doi.org/10.1007/BF02462960
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02462960