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Immune surveillance and neoplasia—II A two-stage mathematical model

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Abstract

In a previous paper (DeLisi and Rescigno, 1977) a model for the interaction of tumor cells and killer lymphocytes was presented. Although that model was highly simplified, the qualitative behavior was in accord with intuitive expectations and a wide range of data. It could not however account forde novo tumor development. In this paper a slightly more realistic model is presented by introducing a delay in the formation of killer lymphocytes. This is done by requiring two stages in the production of a killer. We show that introduction of this second stage allows tumor development from even a single cell, thus removing an important limitation of two variable systems.

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Authors and Affiliations

  1. Laboratory of Theoretical Biology, National Cancer Institute, 20014, Bethesda, MD, U.S.A.

    Aldo Rescigno & Charles DeLisi

Authors
  1. Aldo Rescigno
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  2. Charles DeLisi
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Rescigno, A., DeLisi, C. Immune surveillance and neoplasia—II A two-stage mathematical model. Bltn Mathcal Biology 39, 487–497 (1977). https://doi.org/10.1007/BF02462927

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  • DOI: https://doi.org/10.1007/BF02462927

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