Neuroscience and Behavioral Physiology

, Volume 30, Issue 5, pp 525–533 | Cite as

Localization of NO synthase in lugaro cells and the mechanisms of NO-ergic interaction between inhibitory interneurons in the rabbit cerebellum

  • V. E. Okhotin
  • S. G. Kalinichenko


Purkinje Cell Granule Cell Molecular Layer Cerebellar Cortex Granular Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    S. G. Kalinichenko, V. E. Okhotin, and P. A. Motavkin, “Aspartate aminotransferase of the human cerebellum,”Tsitologiya,37, No. 9/10, 910–914 (1995).Google Scholar
  2. 2.
    S. G. Kalinichenko, V. E. Okhotin, and P. A. Motavkin, “NO-ergic functions of Lugaro and Golgi cells in the rabbit cerebellum,”Tsitologiya,39, No. 2/3, 161–165 (1997).Google Scholar
  3. 3.
    A. B. Melik-Musyan and V. V. Fanardzhyan, “Histological identification of Lugaro cells in the cat cerebellum,”Morfologiya,112, No. 4, 42–45 (1997).Google Scholar
  4. 4.
    V. E. Okhotin, S. G. Kalinichenko, and T. Yu. Gartsman, “The role of nitric oxide in forming inhibitory mechanisms and the phenomenon of long-term depression in the cerebellar cortex,” in:The Role of Nitrogen Monoxide in Life Processes, [in Russian], Polibig, Minsk (1998) pp. 61–64.Google Scholar
  5. 6.
    V. P. Reutov, E. G. Sorokina, V. E. Okhotin, and N. S. Kositsyn,Cyclic Conversion of Nitric Oxide in the Mammal Body, [in Russian], Nauka, Moscow (1997).Google Scholar
  6. 7.
    E. Aoki, R. Semba, and S. Kashiwamata, “New candidates for GABA-ergic neurons in the rat cerebellum: an immunocytochemical study with an anti-GABA antibody,”Neurosci. Lett.,68, 267–271 (1986).PubMedCrossRefGoogle Scholar
  7. 8.
    C. Batini, “Cerebellar localization and localization of GABA and calcium binding protein D28K,”Arch. Ital. Biol.,128, 127–149 (1990).PubMedGoogle Scholar
  8. 9.
    H. Christ, “Fusiform nerve cells of the baboon,”Neurosci. Lett. 56, 195–198 (1985).PubMedCrossRefGoogle Scholar
  9. 10.
    S. Deudonne, “Glycinergic synaptic currents in Golgi cells of the rat cerebellum,”Proc. Natl. Acad. Sci. USA,92, 1441–1445 (1995).CrossRefGoogle Scholar
  10. 11.
    Y. I. Egberongbe, S. M. Gentleman, P. Falkai, et al., “The distribution of nitric oxide synthase immunoreactivity in the human brain,”Neuroscience,59, 561–578 (1994).PubMedCrossRefGoogle Scholar
  11. 12.
    C. A. Fox, “The intermediate cells of Lugaro in the cerebellar cortex of the monkey,”J. Comp. Neurol.,112, 39–53 (1959).PubMedCrossRefGoogle Scholar
  12. 13.
    P. L. A. Gabbott, J. Somogyi, M. G. Stewart, and J. Hamory, “GABA-immunoreactive neurons in the rat cerebellum. A light and electron microscope study,”J. Comp. Neurol.,251, 474–490 (1986).PubMedCrossRefGoogle Scholar
  13. 14.
    A. I. Gulyas, N. Hajos, and T. F. Freund, “Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus,”J. Neurosci,16, 3397–3411 (1996).PubMedGoogle Scholar
  14. 15.
    R. Hawkes and N. Leclerc, “Purkinje cell axon collateral distributions reflect the chemical compartmentation of the rat cerebellar cortex,”Brain Res.,476, 279–290 (1989).PubMedCrossRefGoogle Scholar
  15. 16.
    R. Hawkes, and R. W. Turner, “Compartmentation of NADPH-diaphorase activity in the mouse cerebellar cortex,”J. Comp. Neurol.,346, 499–516 (1994).PubMedCrossRefGoogle Scholar
  16. 17.
    B. T. Hope and S. R. Vincent, “Histochemical characterization of neuronal NADPH-diaphorase,”J. Histochem. Cytochem.,37, 653–661 (1989).PubMedGoogle Scholar
  17. 18.
    M. Ito, “Long-term depression,”Ann. Rev. Neurosci.,12, 85–102 (1989).PubMedCrossRefGoogle Scholar
  18. 19.
    M. Ito and L. Karachot, “Messengers mediating long-term desensitization in cerebellar Purkinje cells,”Neuroreport,1, 129–132 (1990).PubMedCrossRefGoogle Scholar
  19. 20.
    M. Kano, U. Rexhausen, J. Dreessen, and A. Konnerth, “Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells,”Nature,356, 601–604 (1992).PubMedCrossRefGoogle Scholar
  20. 21.
    J. Laine and H. Axelrad, “The candelabrum cell: A new interneuron in the cerebellar cortex,”J. Comp. Neurol. 339 159–173 (1994).PubMedCrossRefGoogle Scholar
  21. 22.
    J. Laine and H. Axelrad, “Morphology of the Golgi-impregnated Lugaro cell in the rat cerebellar cortex: a reappraisal with a description of its axon,”J. Comp. Neurol.,375, 618–640 (1996).PubMedCrossRefGoogle Scholar
  22. 23.
    O. Larsell,The Comparative Anatomy and Histology of the Cerebellum from Monotremes through Primates, University of Minnesota Press, Minneapolis (1970).Google Scholar
  23. 24.
    V. Lev-Ram, T. Jiang, J. Wood, et al., “Synergies and coincidence requirements between NO, cGMP, Ca2+ in the induction of cerebellar long-term depression,”Neuron,18, 1025–1038 (1997).PubMedCrossRefGoogle Scholar
  24. 25.
    V. Lev-Ram, L. R. Makings, P. F. Keitz, et al., “Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients,”Neuron,15, 407–415 (1995).PubMedCrossRefGoogle Scholar
  25. 26.
    D. J. Linden and J. A. Connor, “Long-term synaptic depression,”Ann. Rev. Neurosci.,18, 319–357 (1995).PubMedCrossRefGoogle Scholar
  26. 27.
    E. Lugaro, “Sulle connessioni tra gli elementi neurosi della corticcia cerebellare con considerazioni generali sul sugnificato fisiologico dei rapporti tra gli element nervosi,”Riv. Sper. Freniat. Reggio-Emilia,20, 297–331 (1894).Google Scholar
  27. 28.
    T. Malinski, Z. Taha, S. Grunfeld et al., “Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors,”Biochem. Biophys. Res. Commun. 193, 1076–1082 (1993).PubMedCrossRefGoogle Scholar
  28. 29.
    E. Mugnaini, “The histology and cytology of the cerebellar cortex. The comparative anatomy and histology of the cerebellum,” in:The Human Cerebellum: Cerebellar Connections and Cerebellar Cortex, University of Minnesota Press, Minneapolis (1972), pp. 201–264.Google Scholar
  29. 30.
    E. Mugnaini and A. Floris, “The unipolar brush cell: a neglected neuron of the mammalian cerebellar cortex,”J. Comp. Neurol.,339, 174–180 (1994).PubMedCrossRefGoogle Scholar
  30. 31.
    A. Neki, H. Ohishi, T. Kaneko, et al., “Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum,”Neuroscience,75, 815–826 (1996).PubMedCrossRefGoogle Scholar
  31. 32.
    J. L. O'Leary, J. M. Petty, M. Smith, et al., “Cerebellar cortex of rat and other animals: a structural and ultrastructural study,”J. Comp. Neurol.,134, 401–432 (1968).PubMedCrossRefGoogle Scholar
  32. 33.
    O. P. Ottersen, S. Davanger, and J. Storm-Mathisen, “Glycine-like immunoreactivity in the cerebellum of rat and Senegalese baboon,Papio papio: a comparison with the distribution of GABA-like immunoreactivity and with [3H]glycine and [3H]GABA uptake,”Exp. Bran. Res.,66, 211–221 (1987).Google Scholar
  33. 34.
    O. P. Ottersen, J. Storm-Mathisen, and P. Somogyi, “Localization of glycine-like and GABA-like immunoreactivities in Goligi cell terminals in the rat cerebellum: a postembedding light and electron microscopic study,”Brain Res.,450, 342–353 (1988).PubMedCrossRefGoogle Scholar
  34. 35.
    S. L. Palay and V. Chan-Palay,Cerebellar Cortex, Cytology and Organization, Springer-Verlag, Berlin (1974).Google Scholar
  35. 36.
    R. S. Petralia and R. J. Wenthold, “Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain,”J. Comp. Neurol. 318, 329–354 (1992).PubMedCrossRefGoogle Scholar
  36. 37.
    S. Ramon y Cajal,Textura del Sistema Nervioso del Hombre y de los Vertebrados, Madrid (1904), Vol. II, pp. 337–357.Google Scholar
  37. 38.
    J. H. Rogers, “Immunoreactivity for calretinin and other calcium-binding proteins in cerebellum,”Neuroscience,31, 711–721 (1989).PubMedCrossRefGoogle Scholar
  38. 39.
    M. Sahin and S. Hockfield, “Molecular identification of the Lugaro cell in the cat cerebellar cortex,”J. Comp. Neurol.,301, 575–584 (1990).PubMedCrossRefGoogle Scholar
  39. 40.
    K. Shibuki and D. Okada, “Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum,”Nature,349, 326–328 (1991).PubMedCrossRefGoogle Scholar
  40. 41.
    R. J. Wenthold, R. R. Skaggs, and R. A. Altschuler, “Immunocytochemical localization of aspartate aminotransferase and glutaminase immunoreactivities in the cerebellum,”Brain Res.,363, 371–375 (1986).PubMedCrossRefGoogle Scholar
  41. 42.
    J. Wood and J. Garthwaite, “Models of the diffusional spread of nitric oxide signalling and its pharmacological properties,”Neuropharmacology,33, 1235–1244 (1994).PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • V. E. Okhotin
    • 1
  • S. G. Kalinichenko
    • 1
  1. 1.Laboratory for Neurogenetics and Developmental Genetics Institute of Gene BiologyRussian Academy of SciencesMoscow

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