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Changes in the cholecystokinin-synthesizing system of the hypothalamus in experimental diabetes mellitus in rats

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References

  1. I. G. Akmaev, “Current concepts of the interactions of hypothalamic neurosecretory and the autonomic nervous system in the regulation of endocrine and homeostatic functions,”Morfologiya,102, No. 3, 5–39 (1992).

    Google Scholar 

  2. Yu. M. Kolesnik and A. V. Abramov, “The endocrine functions of the pancreas in experimental diabetes mellitus in rats and its properties during adaptation to hypoxia,”Prob. Éndokrinol.,39, No. 5, 37–40 (1993).

    Google Scholar 

  3. Yu. M. Kolesnik, A. V. Abramov, G. V. Vasilenko, and V. A. Zhulinksii, “Involvement of various parts of the hypothalamus in the pathogenesis of experimental diabetes mellitus in rats,”Prob. Éndokrinol. 41, No. 5, 34–37 (1995).

    Google Scholar 

  4. Yu. M. Kolesnik, G. V. Vasilenko, and A. V. Abramov, “Possible mechanisms for the hypothalamic regulation of the endocrine functions of the pancreas in diabetic mouse line C57BL/KsJ,”Arkh. Patol.,56, No. 4, 56–60 (1994).

    PubMed  Google Scholar 

  5. V. P. Fedotov, N. V. Sadovnikova, and A. V. Chernushkina, “Insulinotropic factors in normal conditions and pathology,”Prob. Éndokrinol.,38, No. 5, 12–17 (1992).

    CAS  Google Scholar 

  6. G. A. Bray, “Nutrient intake is modulated by peripheral peptide administration,”Obesity Res.,3, No. 1, S569-S572 (1995).

    Google Scholar 

  7. S. Ceccatelli, M. Eriksson, and T. Hokfelt, “Distribution and coexistence of corticotropin-releasing factor-, neurotensin-, enkephalin-, cholecystokinin-, galanin-, and vasoactive intestinal polypeptide/peptide histidine isoleukin-like peptides in the parvocellular part of the paraventricular nucleus,”Neuroendocrinology,49, 309–323 (1989).

    PubMed  CAS  Google Scholar 

  8. G. E. Feurle, G. Hamscher, and A. E. Firat, “The role of CCK and its analogs in the organogenesis of the fetal rat pancreas,”Pancreas,10, No. 3, 281–286 (1995).

    PubMed  CAS  Google Scholar 

  9. J. J. Knittel, B. Hafner, D. G. Patel, and E. J. Verspohl, “Stimulation of insulin secretion from pancreatic islets by the cholecystokinin-tetrapeptide analogs Trp-Pro-Asp-Phe-NH2 and Trp-Pro-Asp-Phe (4′-NO2)-NH2,”,Pept. Res.,3, No. 5, 224–227 (1990).

    PubMed  CAS  Google Scholar 

  10. S. F. Leibowitz, “Specificity of hypothalamic peptides in the control of behavioral and physiological processes,”Ann. N.Y. Acad. Sci.,739, 12–35 (1994).

    PubMed  CAS  Google Scholar 

  11. C. Niederau, R. Luthen, and T. Heintges, “Effects of CCK on pancreatic function and morphology,”Ann. N.Y. Acad. Sci.,713, 180–198 (1994).

    PubMed  CAS  Google Scholar 

  12. G. B. Paxinos and C. C. Watson,The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney (1986).

    Google Scholar 

  13. M. Schumacher, H. Coirini, B. S. McEven, and L. Zaborszky, “Binding of [3H]cholecystokinin in the ventromedial hypothalamus is modulated by afferent brain-stem projection but not by ovarian steroids,”Brain Res.,564, No. 1, 102–108 (1991).

    Article  PubMed  CAS  Google Scholar 

  14. A. J. Sipols, D. G. Baskin, and M. Schwartz, “Effects of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression,”Diabetes,44, No. 2, 147–151 (1995).

    PubMed  CAS  Google Scholar 

  15. J. H. Strubbe and A. R. Steffens, “Neural control of insulin secretion,”Horm. Metab. Res.,25, No. 10, 507–512 (1993).

    Article  PubMed  CAS  Google Scholar 

  16. L. W. Swanson and P. E. Sawchenko, “Hypothalamic integration: organization of the paraventricular and supraoptic nuclei,”Ann. Rev. Neurosci.,6, 269–324 (1983).

    Article  PubMed  CAS  Google Scholar 

  17. J. J. Vanderhaegen, F. Lotstra, J. De Mey, and C. Gilles, “Immunohistochemical localization of cholecystokinin and gastrin-like peptides in the brain and hypophysis of rat,”Proc. Natl. Acad. Sci. USA,77, No. 2, 1190–1194 (1980).

    Article  Google Scholar 

  18. G. Williams and S. R. Bloom, “Regulatory peptides, the hypothalamus and diabetes,”Diabet. Med.,6, No. 6, 427–485 (1989).

    Article  Google Scholar 

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Translated from Morfologiya, Vol. 114, No. 6, pp. 27–31, November–December, 1998.

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Abramov, A.V., Kolesnik, Y.M., Trzhetsinskii, S.D. et al. Changes in the cholecystokinin-synthesizing system of the hypothalamus in experimental diabetes mellitus in rats. Neurosci Behav Physiol 29, 621–624 (1999). https://doi.org/10.1007/BF02462475

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