Bulletin of Mathematical Biology

, Volume 42, Issue 1, pp 79–94 | Cite as

Dipole theory of interactions of nerve signals

  • Ling Y. Wei


Based upon the transition rate equation of dipoles in the membrane, we deal with two important aspects of interaction of nerve signals: (1) conditions for nerve excitation and (2) frequency spectrum analysis of nerve impulse. Interrelations between signal amplitudes and frequencies are formulated in detail. There are several important conclusions which can be drawn from our calculations. First, toexcite the nerve, low frequencies are generally more effective than high frequencies. Second, tosedate the nerve (i.e. to suppress undesired activities), high frequencies would suit better. Third, harmonics produced through interactions of nerve signals are not necessarily weaker than the fundamental frequencies. The great significance of our theory is that it indicates in principle the feasibility to alter or rewrite the information contents of a nerve message in our body by applying stimulations of appropriate strengths and frequencies. Thus, the theory provides a physical basis and hence some understanding for a new branch of medicine—neuro therapy such as Nogier's auriculotherapy, Lamy's phonophoresis, Voll's electroacupuncture and the fast rising TENS (transcutaneous electro-neuro stimulation).


Transition Rate Pulse Train Nerve Impulse Nerve Signal Nerve Membrane 
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Copyright information

© Society for Mathematical Biology 1980

Authors and Affiliations

  • Ling Y. Wei
    • 1
  1. 1.Biophysical Research Laboratory, Electrical Engineering DepartmentUniversity of WaterlooWaterlooCanada

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