Neuroscience and Behavioral Physiology

, Volume 27, Issue 2, pp 131–136 | Cite as

Molecular basis of the activity of the dopamine synapse in the mechanisms of learning and amnesia

  • E. K. Podgornaya
  • O. V. Kalkina
  • R. Yu. Il'yuchenok
  • O. V. Polyakov
Article
  • 24 Downloads

Abstract

The neurochemical correlates of dopamine synapse activity were studied during the retrieval of memory traces and in the absence of retrieval (“psychogenic” amnesia). The physiochemical parameters of D2 receptor function, the synaptic membrane, and the catechol content were assessed in various regions of the brain (striatum, neostriatum, hypothalamus, amygdala, frontal cortex, hippocampus, nucleus accumbens, and nuclei A9 and A10) in intact, trained, and amnesiac rats. It was demonstrated that disturbances in memory trace retrieval were associated with decreased activation of synaptic dopamine receptors and alterations in the dopamine transformation pathway in the rat brain.

Keywords

Frontal Cortex Dopaminergic System Receptor Density Synaptic Cleft Synaptic Membrane 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E. K. Podgornaya, O. V. Galkina, and O. V. Polyakov, “The formation ofp-tyramine bound by receptors of synaptic membranes of the rat brainin vitro”, Ukr. Biokhim. Zh.,61, No. 6, 27 (1989).Google Scholar
  2. 2.
    E. K. Podgornaya, O. V. Galkina, and R. O. Il'yuchenok, “The binding of3H-dopamine by DA2 receptors of the synaptic membranes of difference areas in the rat brain after training to a conditioned passive escape reflex”, Neirokhimiya,9, No. 3, 301 (1990).Google Scholar
  3. 3.
    O. V. Polyakov, E. K. Podgornaya, and O. V. Galkina, “The transformation of dopamine specifically bound by receptors of synaptic membranes on exposure to anodic microdischarges in an electrolyte solution”, Khimiya Vysokikh Énergii,25, No. 1, 85 (1991).Google Scholar
  4. 4.
    O. Civelli, J. Bunzow, and D. K. Grandy, “Molecular diversity of the dopamine receptor”, Ann. Rev. Pharmacol. Toxicol.,32, 281 (1993).CrossRefGoogle Scholar
  5. 5.
    M. E. Jarvic and R. Kopp, “An improved one-trial passive avoidance learning situation”, Psychol. Rep.,21, No. 2, 221 (1967).Google Scholar
  6. 6.
    C. Kaiser and T. Jain, “Dopamine receptors: functions, subtypes, and emerging concepts”, Med. Res. Rev.,5, No. 2, 145 (1985).PubMedGoogle Scholar
  7. 7.
    P. M. Laduron, “Molecular characteristics of dopamine receptors”, in: Neurotransmitter Interactions in the Basal Ganglia, Sandler et al. (eds.), Raven Press, New York (1987), p. 219.Google Scholar
  8. 8.
    K. Moroi and L. L. Hsu, “A brain synaptic dopamine-binding protein: isolation and partial characterization”, J. Neurosci. Res.,12, 112 (1984).CrossRefGoogle Scholar
  9. 9.
    B. K. Podgornaya, O. V. Polyakov, and O. V. Rudenko, “Molecular basis of synaptic function for NIM (in vivo andin vitro models)”, Second International Congress of ISNIM, Paestum (Salerno), Italy (September 1993), p. 260.Google Scholar
  10. 10.
    E. K. Podgornaya, O. V. Polyakov, and O. V. Rudenko, “Structural and stereochemical requirements for DA-membrane-receptor interaction”, Abstracts of 7th International Catecholamine Symposium, Amsterdam (June 1992), p. 36.Google Scholar
  11. 11.
    E. K. Podgornaya, O. V. Polyakov, and O. V. Galkina, “The synaptic regulation of the DA-receptor structure-activity relationships after DA release”, Abstracts of XXXII Congress of the International Union of Physiological Sciences, Glasgow (August 1993), p. 170.Google Scholar
  12. 12.
    E. K. Podgornaya, O. V. Galkina, and O. V. Polyakov, “The role of redox reactions in synaptic plasticity”, Abstracts of the 7th International Catecholamine Symposium, Amsterdam (June 1992), p. 260.Google Scholar
  13. 13.
    H. Ueda, Y. Goshima, and Y. Miau, “Presynaptic regulation of endogenous catecholamine release from slices of rat hypothalamus”, J. Pharmacol. Dyn.,6, 54(1983).Google Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • E. K. Podgornaya
  • O. V. Kalkina
  • R. Yu. Il'yuchenok
  • O. V. Polyakov

There are no affiliations available

Personalised recommendations